Celapram

Pajjiż: Awstralja

Lingwa: Ingliż

Sors: Department of Health (Therapeutic Goods Administration)

Ingredjent attiv:

Citalopram hydrobromide; Citalopram

Disponibbli minn:

Alphapharm Pty Ltd

Klassi:

Medicine Registered

Fuljett ta 'informazzjoni

CELAPRAM

_contains the active ingredient citalopram hydrobromide_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Celapram.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Celapram against
the benefits expected for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT CELAPRAM IS
USED FOR
Celapram is used to treat depression.
Celapram belongs to a group of
medicines called selective serotonin
reuptake inhibitors (SSRIs). They are
thought to work by acting on
chemicals in your brain called
amines. These amines are involved in
controlling mood.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY CELAPRAM HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed
Celapram for another reason.
Celapram is available only with a
doctor's prescription.
BEFORE YOU TAKE
CELAPRAM
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE CELAPRAM IF YOU HAVE
A CONDITION CALLED 'CONGENITAL LONG
QT SYNDROME. AT HIGH DOSES,
CELAPRAM CAN CAUSE CHANGES IN THE
WAY THAT YOUR HEART BEATS.
SEE YOUR DOCTOR IMMEDIATELY IF YOU
EXPERIENCE AN IRREGULAR HEARTBEAT,
SHORTNESS OF BREATH, DIZZINESS OR
FAINTING WHILE TAKING CELAPRAM.
DO NOT TAKE CELAPRAM IF YOU ARE
ALLERGIC TO MEDICINES CONTAINING
CITALOPRAM HYDROBROMIDE (E.G.
CIPRAMIL) OR ANY OF THE INGREDIENTS
LISTED AT THE END OF THIS LEAFLET.
Some symptoms of an allergic
reaction include skin rash, itching or
hives; swelling of the face, lips or
tongue which may cause difficulty in
swallowing or breathing; wheezing
or shortness of breath.
DO NOT TAKE CELAPRAM IF YOU ARE
TAKING PIMOZIDE (ORAP), A
MEDICINE FOR SCHIZOPHRENIA.
Combining Celapram and pimozide
may lead to electrical disturbances in
the heart.
DO NOT TAKE CELAPRAM IF YOU ARE
TAKING ANOTHER MEDICINE FOR
DEPRESSI

Karatteristiċi tal-prodott

CELAPRAM 
_Citalopram hydrobromide _

PRODUCT INFORMATION 
NAME OF THE MEDICINE 
Active ingredient: 
Citalopram hydrobromide 
Chemical name: 
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-
isobenzofurancarbonitrile monohydrobromide. The active
is present as a racemate. 
Structural formula: 

Molecular formula: 
C
20
H
21
FN
2
O, HBr 

Molecular weight: 
405.3 

CAS Registry no.: 
59729-32-7 
DESCRIPTION 
Citalopram hydrobromide is a white or almost white crystalline powder, odourless or practically odourless.  
Citalopram hydrobromide is soluble in methanol, sparingly soluble in water and acetone, soluble in ethanol 
(96%), freely soluble in chloroform and very slightly soluble in diethylether.  No polymorphic forms have 
been observed.  
Excipients  in  Celapram  includemaize  starch,  lactose,  microcrystalline  cellulose,  povidone,  crospovidone, 
macrogol 4000,
magnesium stearate, hypromellose and titanium dioxide. 
PHARMACOLOGY 
Biochemical  and  behavioural  studies  have  shown  that  citalopram  is  a  potent  inhibitor  of  5-
hydroxytryptamine (5-HT, serotonin) uptake.  Tolerance to the inhibition of 5-HT-uptake is not induced by 
long-term treatment with citalopram.  
_In vitro _studies indicate that citalopram is one of the most selective Serotonin Reuptake Inhibitor (SSRI) yet 
developed,  with  little  or  no  effect  on  the  uptake  of  noradrenaline  (NA),  dopamine  (DA)  and  gamma 
aminobutyric  acid  (GABA).    In  comparison  with  other  SSRIs,  the  decreasing  order  of  selectivity  is 
CELAPRAM 
– Product Information 
2 

escitalopram, citalopram, sertraline, paroxetine, fluvoxamine and
fluoxetine.  The clinical relevance of this _in _
_vitro _finding has not been established.  
In contrast to m