ZORAX CREAM 5% WW

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ACYCLOVIR

Boleh didapati daripada:

SUNWARD PHARMACEUTICAL SDN. BHD.

INN (Nama Antarabangsa):

ACYCLOVIR

Unit dalam pakej:

10gm mcg/mL; 10 gm mcg/mL; 5 gm mcg/mL; 15 gm; 30 gm; 12 gm; 400 gm

Dikeluarkan oleh:

SUNWARD PHARMACEUTICAL SDN. BHD.

Risalah maklumat

ZORAX CREAM 5% W/W
Acyclovir (5% w/w)
_ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1. What Zorax Cream is used for
2. How Zorax Cream works
3. Before you use Zorax Cream
4. How to Zorax Cream
5. While you are using it
6. Side effects
7. Storage and disposal of Zorax Cream
8. Product description
9. Manufacturer and Product Registration
Holder
10.Date of revision
WHAT ZORAX CREAM IS USED FOR
It
is
used
for
the
topical
treatment
of
Herpes
simplex
virus
infections
(cold
sores)
of
the
skin
including
initial
and
recurrent
herpes
genitalis
(sexually
transmitted infection at genital area) and
herpes labialis (infection of lip, mouth or
gums).
HOW ZORAX CREAM WORKS
The active ingredient in the medicine
is
Acyclovir.
Acyclovir
is
an
antiviral
medicine. It works by reducing the severity
and duration of cold sores symptoms.
BEFORE YOU USE ZORAX CREAM
_- When you must not use it _
If you are allergic or hypersensitive with
acyclovir or any of the other ingredients
listed at the end of this leaflet.
_- Before you start to use it _
Tell your doctor if you are:-

Breastfeeding

Pregnant
_- Taking other medicines _
Please consult your doctor or pharmacist
before you take any other medicine, as the
interaction between zorax cream and other
medicines are not known since zorax cream
applied topically is not absorbed in your
body.
HOW TO USE ZORAX CREAM_ _
_- How much to use _
Apply
sufficient
quantity
to
adequately
cover all lesions every 3 or 4 hours 5 or 6
times daily for5 to 10 days. A finger cot or
rubber glove should be used when applying
Zorax
Cream to prevent transmission of
infection
to
other
body
sites
or
other
persons
_ _
_- When to use it _
Follow the instructions given to you by
your doctor or pharmacist.
_ _
_- How long to use it _
It is important to take Zorax Cream as long
as your doctor prescribes.
_ _
_- If you forget to use it _
Do not take extra dose to make up for a
missed dose. Just take your next dose at
usual time.
_- If you use too much (overdose) _
Contact your doctor imme

Ciri produk

FURTHER INFORMATION CONCERNING THIS DRUG CAN BE OBTAINED FROM YOUR
FAMILY
PHYSICIAN / LOCAL GENERAL PRACTITIONER / PHARMACIST.
Manufacturer & Product Registration Holder:
SUNWARD PHARMACEUTICAL SDN. BHD.
No. 9 ,11&17, Jalan Kempas 4,
Taman Perindustrian Tampoi Indah,
81200 Johor Bahru, Johor, Malaysia.
EL227A-R9
Revision Date: 13/12/2022
PRODUCT DESCRIPTION:
White, smooth, water-miscible cream.
PHARMACODYNAMICS:
Acyclovir is a synthetic acyclic purine nucleoside analogue with in
vitro inhibitory activity against
herpes
simplex
type
1
(HSV-1)
and
type
2
(HSV-2),
varicella
zoster,
Epstein-Barr
and
cytomegalovirus. In cell cultures, the inhibitory activity of
acyclovir for herpes simplex virus is
highly selective. Cellular thymidine kinase does not effectively
utilize acyclovir as a substrate.
Herpes
simplex
virus-coded
thymidine
kinase,
however,
converts
acyclovir
into
acyclovir
monophosphate, a nucleotide. The monophosphate is further converted
into diphosphate by
cellular guanylate kinase and into triphosphate by a number of
cellular enzymes. Acyclovir
triphosphate interferes with herpes simplex virus α-DNA polymerase
and inhibits viral DNA
replication. Acyclovir triphosphate also inhibits cellular α-DNA
polymerase but to a lesser degree.
In vitro, acyclovir triphosphate can be incorporated into growing
chains of DNA by viral DNA
polymerase and to a much smaller extent by cellular α-DNA polymerase.
When incorporation
occurs, the DNA chain is terminated. Acyclovir is preferentially taken
up and selectively converted
to the active triphosphate form by herpes virus infected cells. Thus,
acyclovir is much less toxic in
vitro for normal uninfected cells because: 1) less is taken up 2) less
is converted to the active form
3) cellular α-DNA polymerase is less sensitive to the effects of the
active form.
PHARMACOKINETICS:
Absorption of acyclovir is usually slight following topical
application to intact skin, although it may
be increased by changes in formulation.
INDICATION:
It is indicated for the topical treatment