Zidovex LN (Lamivudine 150mg Zidovudine 300mg Nevirapine 200mg Tablets)

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

NEVIRAPINE; ZIDOVUDINE/AZIDOTHYMIDINE; LAMIVUDINE

Boleh didapati daripada:

UNIMED SDN BHD

INN (Nama Antarabangsa):

NEVIRAPINE; ZIDOVUDINE/AZIDOTHYMIDINE; LAMIVUDINE

Unit dalam pakej:

60tablet Tablets

Dikeluarkan oleh:

Aurobindo Pharma Limited (Unit III),

Risalah maklumat

ZIDOVEX LN
(
LAMIVUDINE 150mg, ZIDOVUDINE 300mg, NEVIRAPINE 200mg Tablets
)
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What
LAMIVUDINE
150mg,
ZIDOVUDINE 300mg, NEVIRAPINE
200mg Tablet is used for
2.
How
LAMIVUDINE
150mg,
ZIDOVUDINE 300mg, NEVIRAPINE
200mg Tablets works
3.
Before you take LAMIVUDINE 150mg,
ZIDOVUDINE 300mg, NEVIRAPINE
200mg Tablets
4.
How
to
take
LAMIVUDINE
150mg,
ZIDOVUDINE 300mg, NEVIRAPINE
200mg Tablets
5.
While
you
are
using
LAMIVUDINE
150mg,
ZIDOVUDINE
300mg,
NEVIRAPINE 200mg Tablets
6.
Side effects
7.
Storage and Disposal of LAMIVUDINE
150mg,
ZIDOVUDINE
300mg,
NEVIRAPINE 200mg Tablets
8.
Product description
9.
Manufacturer
10.
Marketing
Authorization
Holder
11.
Date of Revision
WHAT
LAMIVUDINE
150MG,
ZIDOVUDINE 300MG, NEVIRAPINE
200MG TABLETS IS USED FOR
LAMIVUDINE 150mg, ZIDOVUDINE
300mg, NEVIRAPINE 200mg Tablets are
indicated
for
the
treatment
of
HIV-1
infection
in
adults.
They
are
not
recommended
for
use
in
children
or
adolescents,
as
there
is
insufficient
information available.
HOW
LAMIVUDINE
150MG,
ZIDOVUDINE 300MG, NEVIRAPINE
200MG TABLETS
WORKS
LAMIVUDINE 150mg, ZIDOVUDINE
300mg,
NEVIRAPINE
200mg
Tablets
contain
a
combination
of
3
drugs
–
lamivudine,
zidovudine
and
nevirapine
–
used for the treatment of persons infected
with HIV, the virus that causes AIDS. Since
LAMIVUDINE
150mg,
ZIDOVUDINE 300mg, NEVIRAPINE
200mg Tablets combine all 3 anti-HIV drugs
in a single tablet; they are more convenient
for you
to
take
all
your
drugs
regularly
without having to swallow 3 separate pills.
LAMIVUDINE 150mg, ZIDOVUDINE
300mg, NEVIRAPINE 200mg Tablets work
by lowering the amount of HIV in the blood
(called ‘viral load’) and keeps it at a low
level.
LAMIVUDINE
150mg,
ZIDOVUDINE 300mg,
NEVIRAPINE
200mg Tablets increase your bodies supply
of CD4 cells, which are a type of white blood
cells
that
play
an
important
role
in
maintaining a healthy immune system to
help fight infection.
LAMIVUDINE 150mg, ZIDOVUDINE
300mg, NEVIRAPINE 200mg Tablets will
not cure your

Ciri produk

ZIDOVEX LN
(LAMIVUDINE 150MG, ZIDOVUDINE 300MG, NEVIRAPINE 200MG TABLETS)
PRODUCT DESCRIPTION
White, capsule shaped, biconvex film coated tablets debossed with
“C” on one side and "72"on
other side.
Each tablet contains lamivudine 150mg, zidovudine 300mg, and
nevirapine 200mg.
PHARMACODYNAMICS
_LAMIVUDINE _
Lamivudine, a synthetic antiretroviral agent, is a nucleoside reverse
transcriptase inhibitor. The
drug is a dideoxynucleoside reverse transcriptase inhibitor.
Lamivudine is the negative enantiomer
of a dideoxy analog of cytidine and is structurally similar to
zalcitabine. Lamivudine differs
structurally from zalcitabine in that the 3’-carbon of the ribose
ring is replaced with sulfur, forming
an oxathiolane ring. The absence of a free 3’-hydroxyl group on the
oxathiolane ring results in the
inability of lamivudine to form phosphodiester linkages at this
position.
Both the positive and negative enantiomers of 2’3’-dideoxy,
3’-thiacytidine exhibit antiviral
activity in vitro, but lamivudine appears to exhibit greater antiviral
activity and to be considerably
less cytotoxic than the positive enantiomer.
Following conversion to a pharmacologically active metabolite,
lamivudine apparently inhibits
replication of human retroviruses by interfering with viral
RNA-directed DNA polymerase (reverse
transcriptase). Lamivudine therefore exerts a virustatic effect
against retroviruses by acting as a
reverse transcriptase inhibitor.
The antiviral activity of lamivudine appears to depend on
intracellular conversion of the drug to a
5’-triphosphate metabolite; thus, 2’, 3’-dideoxy,
3’-thiacytidine-5’-triphosphate (3TC-TP) and not
unchanged lamivudine appears to be the pharmacologically active form
of the drug. 3TC-TP is a
structural
analog
of
deoxycytidine
triphosphate
(dC-TP),
the
natural
substrate
for
reverse
transcriptase (viral RNA-directed DNA polymerase). Although other
mechanisms may be involved
in the antiretroviral activity of the drug, 3TC-TP appears to compete
with naturally occurring dC-
TP