VALZAAR H TABLETS (160 MG + 12.5 MG)

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

VALSARTAN; HYDROCHLOROTHIAZIDE

Boleh didapati daripada:

LABORATORIES TORRENT (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

VALSARTAN; HYDROCHLOROTHIAZIDE

Unit dalam pakej:

98tablet Tablets; 28tablet Tablets

Dikeluarkan oleh:

TORRENT PHARMACEUTICALS LTD

Risalah maklumat

VALZAAR H TABLETS
_ _
Valsartan and Hydrochlorothiazide (160mg+12.5mg)
_ _
_ _
1
_ _
_ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What is VALZAAR H used for.
2.
How VALZAAR H works.
3.
Before you use VALZAAR H.
4.
How to use VALZAAR H.
5.
While you are using it.
6.
Side effects.
7.
Storage
and
Disposal
of
VALZAAR H.
8.
Product Description.
9.
Manufacturer
and
Product
Registration Holder.
10.
Date of revision.
WHAT VALZAAR H IS USED FOR
VALZAAR
H
is
a
prescription
medicine used in adults to lower high
blood pressure (hypertension).
HOW VALZAAR H WORKS
VALZAAR
H
belongs
to
a
class
of
medicines which help to control high
blood pressure. VALZAAR H works by
blocking
the
effect
of
angiotensin
II
which cause increase in blood pressure.
As
a
result,
blood
vessels
relax
and
blood pressure is lowered.
BEFORE YOU USE VALZAAR H
-
_When you must not use it _
Do not take VALZAAR H:
•
If you are allergic (hypersensitive)
to valsartan or hydrochlorothiazide
or any of the other ingredients of
VALZAAR H.
•
If you have severe liver disease.
_Pregnancy and lactation_
Do not take VALZAAR H if you are
pregnant, trying to get pregnant or think
you
may
be
pregnant.
If
you
get
pregnant while taking VALZAAR H,
stop taking it immediately and contact
your doctor.
Do not take VALZAAR H if you are
breast-feeding.
Ask
your
doctor
or
pharmacist for advice before taking any
medicine.
-
_Before you start to use it _
You must be especially careful and talk
to
your
doctor
before
taking
VALZAAR H if any of the following
apply to you.
•
If you have liver disease.
•
If you have severe kidney disease
or if you are undergoing dialysis.
•
If
you
are
suffering
from
a
narrowing of the kidney artery.
•
If
you
have
recently
undergone
kidney transplantation (received a
new kidney).
•
If
you
are
being
treated
after
a
heart
attack
or
for
heart
failure.
Your
doctor
may
check
your
kidney function.
•
If
you
have
autoimmune
disease
(immune system attacking healthy
body cells and tissues), swelling or
edema, severe he

Ciri produk

PRODUCT NAME
:
ITEM / PACK
:
DESIGN STYLE
:
CODE
:
DIMENSIONS (MM)
:
ART WORK SIZE
:
DATE : 23-06-2022
Reviewed By
NO. OF COLORS: 1
COUNTRY : Malaysia
Front / Back
Valzaar H
Insert
S/S
180 x 390
xxxxxxxxx-5253
Black
PANTONE SHADE NOS.:
ACTIVITIES
DEPARTMENT
NAME
SIGNATURE
DATE
Prepared By
PKG.DEV
PKG.DEV
LOCATION :
Indrad
QUALITY
Approved By
BRAND OR PRODUCT NAME
VALZAAR H TABLETS (160 MG + 12.5 MG)
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
VALSARTAN AND HYDROCHLOROTHIAZIDE TABLETS USP 160 MG +12.5 MG
Each film coated tablet contains:
Valsartan USP 160 mg
Hydrochlorothiazide USP 12.5 mg
PRODUCT DESCRIPTION
VALZAAR H TABLETS (160 MG + 12.5 MG):
Pink colored, oval shaped, beveled edge, biconvex, film coated tablets
debossed
with “1072” on one side and plain on other side.
DOSAGE FORM
Film coated Tablets
PHARMACODYNAMICS / PHARMACOKINETICS
PHARMACODYNAMICS
The active hormone of the Renin-Angiotensin-Aldosterone System (RAAS)
is
angiotensin II, which is formed from angiotensin I through ACE.
Angiotensin II binds
to specific receptors located in the cell membranes of various
tissues. It has a wide
variety of physiological effects, including in particular both direct
and indirect
involvement in the regulation of blood pressure. As a potent
vasoconstrictor,
angiotensin II exerts a direct pressor response. In addition, it
promotes sodium
retention and stimulation of aldosterone secretion.
Valsartan is an orally active and specific angiotensin II (Ang II)
receptor antagonist.
It acts selectively on the AT1 receptor subtype, which is responsible
for the known
actions of angiotensin II. The increased plasma levels of Ang II
following ATl
receptor blockade with valsartan may stimulate the unblocked AT2
receptor, which
appears to counterbalance the effect of the AT1 receptor. Valsartan
does not exhibit
any partial agonist activity at the AT1 receptor and has much greater
affinity for the
AT1 receptor than for the AT2 receptor.
Valsartan does not inhibit ACE, also known as kininase II, which
converts Ang I to
Ang II and deg