Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CEPHALEXIN MONOHYDRATE
Duopharma Marketing Sdn. Bhd.
CEPHALEXIN MONOHYDRATE
10x10 Capsules
KOTRA PHARMA (M) SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ UPHALEXIN CAPSULE Cephalexin Monohydrate equivalent to Cephalexin (250mg & 500mg) 1 WHAT IS IN THIS LEAFLET 1. What Uphalexin Capsule is used for 2. How Uphalexin Capsule works 3. Before you use Uphalexin Capsule 4. How to use Uphalexin Capsule 5. While you are using it 6. Side effects 7. Storage and Disposal of Uphalexin Capsule 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT UPHALEXIN CAPSULE IS USED FOR Uphalexin Capsule is an antibiotic which is indicated in the treatment of the following infections due to susceptible microorganisms: • Respiratory tract infections • Otitis media (ear infection) • Bone infections • Genitourinary (urinary) tract infections, including acute prostatitis • Dental infections HOW UPHALEXIN CAPSULE WORKS Cephalexin is an antibiotic that belongs to the group of medicines called cephalosporin. These medicines work by killing or stopping the growth of the bacteria, which cause infections. BEFORE YOU USE UPHALEXIN CAPSULE _-When you must not use it _ Do not take Uphalexin Capsule if: • You are allergic or hypersensitive to cephalosporin. • It is not prescribed by a qualified doctor or pharmacist for you. • You are pregnant, trying to get pregnant or think you may be pregnant. • You are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine. _-Before you start use it _ Tell your doctor if: • You are allergic to any medicines, food and dyes. • You are taking any other medicines (including those not prescribed by your doctor). • You are allergic or hypersensitive to Penicillin. • You are having renal impairment. • You are pregnant and nursing mother. _-Taking other medicines _ You should tell your doctor if you are taking the following medicine as it may interact with your Uphalexin Capsule: • Oestrogen containing oral contraceptives (birth control pill). • Probenecid (medicines used to treat chronic gout and gouty arthritis). • N Baca dokumen lengkap
COMPOSITION PHARMACOKINETICS INDICATIONS PHARMACODYNAMICS Each capsule contains: Uphalexin Capsule 500mg: Cephalexin Monohydrate equivalent to Cephalexin 500mg Uphalexin Capsule 250mg: Cephalexin Monohydrate equivalent to Cephalexin 250mg Uphalexin Capsule 500mg: Pink/purple hard gelatin capsule, size 0 Uphalexin Capsule 250mg: Pink/Ruby red hard gelatin capsule, size 2 Cephalexin is bactericidal; its action depending on its ability to bind penicillin-binding proteins located in bacterial cytoplasmic membranes. Cephalexin inhibits synthesis of bacterial septum and cell wall pr obably by acylation of transpeptidases enzymes. These enzymes are responsible for the cross linking of peptidoglycan chains, which is necessary for the bacterial cell wall strength and rigidity. Cell division and growth are also inhibited. Rapidly dividing bacteria are those most susceptible to the action of cephalexin. Cephalexin is almost completely absorbed from the gastrointestinal tract. If cephalexin is taken with food, absorption may be delayed, but the total amount absorbed is not appreciably altered. It is widely distributed in the body but does not enter the cerebrospinal fluids in significant quantities. It is not metabolised. About 80% or more of a dose is excreted unchanged in the urine. Contraindicated in patient hypersensitive to cephalosporin. Cephalexin should be used with caution for patient with penicillin sensitivity. False positive urinary glucose and false positive Combs’ test have been found during the treatment of Cephalexin. Patients with renal impairment should be given with caution. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including cephalexin, and may range from mild to life threatening. Therefore, it is important to consider this diagnosis in patients with diarrhea subsequent to the administration of cephalexin. Prolonged use of cephalexin may result in the overgrowth of nonsusceptible organisms. Careful observation of the patients is essential. If superinfection occurs Baca dokumen lengkap