UNISON GLUCOSAMINE 500MG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Glucosamine Sulfate Potassium Chloride

Boleh didapati daripada:

UNISON NUTRACEUTICALS SDN. BHD.

INN (Nama Antarabangsa):

Glucosamine Sulfate Potassium Chloride

Unit dalam pakej:

30 Tablets; 90 Tablets

Dikeluarkan oleh:

UNISON NUTRACEUTICALS SDN. BHD.

Risalah maklumat

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_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
UNISON GLUCOSAMINE 500MG TABLET
_ _
Glucosamine Sulfate-Potassium Chloride 699.00mg equivalent to
Glucosamine sulfate 500.00mg
1
WHAT IS IN THIS LEAFLET
1.
What
_Glucosamine 500mg Tablet _
is
used for
2.
How
_Glucosamine 500 _
works
3.
Before you use
_Glucosamine 500_
4.
How to use
_Glucosamine 500_
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
_Glucosamine 500_
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT GLUCOSAMINE 500 IS USED FOR:
_Glucosamine 500_
is used as an
adjunctive therapy in osteoarthritis
HOW _GLUCOSAMINE 500 _WORKS:
_Glucosamine _
_500 _
provides
relief
to
sufferers
of
arthritis
by
reducing
joint
inflammation
and
relieving
associated
pain
BEFORE YOU USE _GLUCOSAMINE 500 _
For those with type 2 diabetics and those
who have problems with glucose
tolerance whom consumed glucosamine
and anti-inflammatory drug (in case of
severe pain), please ensure that their
blood sugar carefully monitored during
the first day of the treatment.
-
_Taking other medicines _
Tell your doctor if you are taking any
other medicines, including any that
you buy without a prescription from a
pharmacy, supermarket or health food
shop.
Diabetic
patients
should
take
glucosamine
under
medical
supervision.
-
_Pregnancy and lactation _
Pregnancy and lactation, as for other
drugs, this tablet should be given under
medical supervision.
_ _
HOW TO USE _Glucosamine 500 _
Light to moderate : 1 tablet twice daily,
15 minutes before meals for at least 6
weeks. (or according to medical
prescription)
Severe osteoarthrithis symptoms -
Initial Therapy: 1 tablet 3 times daily,
15 minutes before meals for at least 8
weeks.
Follow up therapy: Maintenance
therapy should be followed for 3-4
months (or according to medical
prescription) by admission of 1 tablet
taken 2 times daily, 15 minutes before
meals. The treatment should be
repeated every other 6 months or less
according to medical prescription.
To be

Ciri produk

PILG500
Revised 18/9/2019
UNISON GLUCOSAMINE 500 TABLET
DESCRIPTION:
This tablet is white to off white, oval shaped, plain, film-coated
tablet, 16.6mm in length.
COMPOSITION:
Each tablet contains Glucosamine Sulphate-Potassium chloride 699.00mg
equivalent to Glucosamine sulphate 500.00 mg
.
PHARMACODYNAMICS:
Glucosamine metabolic actions on articular cartilage include the
stimulation of proteoglycan synthesis by cultivated human chondrocytes
a nd protection
against the metabolic impairment induced by some NSAIDs in vitro.
Glucosamine appears to affect specifically the synthesis of monomeric
proteoglycan
aggregates, since lower size proteoglycan identified by gel filtration
on Sepharose Cl-2B only represent a minor portion of the total
immunoreactive
proteoglycan.
In
normal
human
adult chondrocytes
in
vitro,
Glucosamine
increases
aggrecan
protein
mRNA.
Hellio et al recently observed that Glucosamine induced an increase of
protein synthesis in human osteoarthritis chondrocytes in vitro. Based
on these
results, it is suggested that Glucosamine acts through an increase of
sulphated glycosaminoglycans synthesis, which in turn, induces
proteoglycan core
protein production by human chondrocytes. Such an explanation is
supported by the fact that Glucosamine stimulates SO4 uptake in rat
articular cartilage in
vitro. Similar results were also achieved in ex vivo experiments
following treatment of animals for 14 days with oral Glucosa mine.
Analysed together, these
experiments suggest that Glucosamine is able to stimulate
glycosaminoglycans production and the synthesis of proteoglycan.
Glucosamine has also
showed in vitro anti-catabolic properties suppressing collagenase
activity and increasing the diminished adhesion of chondrocytes to
fibronectin i n fibrillated
cartilage. Glucosamine has been shown to possess anti-inflammatory
activities in different in vivo animal models without inhibiting the
synthesis of
prostaglandins.
PHARMACOKINETICS:
Upon consumption of this product, the tablet disintegrates in the
stomach to rele