TORIDIP 20mg Tablets

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

LERCANIDIPINE HYDROCHLORIDE

Boleh didapati daripada:

LABORATORIES TORRENT (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

LERCANIDIPINE HYDROCHLORIDE

Unit dalam pakej:

28tablet Tablets

Dikeluarkan oleh:

TORRENT PHARMACEUTICALS LTD.

Risalah maklumat

TORIDIP TABLETS
Lercanidipine Hydrochloride Tablets 10mg, 20mg
1
_Consumer Medication Information Leaflet (RiMUP)_
_ _
WHAT IS IN THIS LEAFLET
1.
What Toridip is used for
2.
How Toridip works
3.
Before you use Toridip
4.
How to use Toridip
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Toridip
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT TORIDIP IS USED FOR
Toridip contains Lercanidipine. Toridip
is used to treat high blood pressure also
known as hypertension in adults over the
age of 18 years.
HOW TORIDIP WORKS
Toridip belongs to a group of medicines
called Calcium Channel Blockers. The
mechanism of its antihypertensive action
is
due
to
a
direct
relaxant
effect
on
vascular
smooth
muscle
thus
lowering
total peripheral resistance.
BEFORE YOU USE TORIDIP
_When you must not use it _

If you are allergic (hypersensitive) to
lercanidipine hydrochloride or to any
other ingredients of Toridip tablets.

If you have had allergic reactions to
drugs closely related to Toridip tablets
( such as amlodipine, nicardipine,
felodipine,
isradipine,
nifedipine
or
lacidipine).

If you are suffering from certain heart
diseases:
•
Untreated heart failure.
•
Obstruction to flow of blood from
the heart.
•
Unstable angina (angina at rest or
progressively increasing).
•
Within one month of heart attack.

If
you
have
severe
liver
or
kidney
problems.

If
you
are
taking
drugs
that
are
inhibitors of CYP3A4 isoenzyme:
•
Antifungal
medicines
(such
as
ketoconazole or itraconazole)
• Macrolide
antibiotics
(such
as
erythromycin or troleandomycin)
• Antivirals (such as ritonavir)

If you are taking another drug called
ciclosporin or cyclosporin (used after
transplants to prevent organ rejection)

With grapefruit or grapefruit juice.

Do
not
use
if
you
are
pregnant
or
breast feeding.
_Before you start use it _
Please
tell
your
doctor
if
you
are
suffering or have ever suffered from any
of the following conditions or illnesses:

You
have

Ciri produk

Proposed Prescribing Information
For the use of a Registered Medical Practitioner or a Hospital or a
Laboratory
TORIDIP 10 MG TABLETS AND TORIDIP 20 MG TABLETS
LERCANIDIPINE HYDROCHLORIDE TABLETS
BRAND OR PRODUCT NAME
TORIDIP 10 mg Tablets
TORIDIP 20 mg Tablets
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
TORIDIP 10 mg Tablets
Each film coated tablet contains:
Lercanidipine Hydrochloride…….10mg
equivalent to Lercanidipine……..9.4 mg
Colours: Yellow oxide of Iron & Titanium dioxide
TORIDIP 20 mg Tablets
Each film coated tablet contains:
Lercanidipine Hydrochloride…….20mg
equivalent to Lercanidipine ………..18.8 mg
Colours: Red oxide of Iron & Titanium dioxide
PRODUCT DESCRIPTION
TORIDIP 10 mg Tablets
Yellow coloured round, shaped biconvex, film coated tablets with
break-line on one side and plain on other side.
TORIDIP 20 mg Tablets
Pink coloured round, shaped biconvex, film coated tablets with
break-line on one side and plain on other side.
DOSAGE FORM
Film coated tablet
PHARMACODYNAMICS / PHARMACOKINETICS
PHARMACODYNAMICS
Selective calcium channel blockers with mainly vascular effects
ATC code: C08CA13
Lercanidipine is a calcium antagonist of the dihydropyridine group and
inhibits the transmembrane influx of
calcium into cardiac and smooth muscle. The mechanism of its
antihypertensive action is due to a direct relaxant
effect on vascular smooth muscle thus lowering total peripheral
resistance. Despite its short pharmacokinetic
plasma half-life,
lercanidipine is endowed with a prolonged antihypertensive activity
because of
its high
membrane partition coefficient, and is devoid of negative inotropic
effects due to its high vascular selectivity.
Since the vasodilatation induced by Lercanidipine is gradual in onset,
acute hypotension with reflex tachycardia
has
rarely been observed in hypertensive patients.
As
for
other
asymmetric
1,4-dihydropyridines,
the
antihypertensive activity of lercanidipine is mainly due to its
(S)-enantiomer.
PHARMACOKINETICS
Lercanidipine is completely absorbed from the gastroint