THYROSIT 100 MCG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

THYROXINE SODIUM

Boleh didapati daripada:

IDAMAN PHARMA SDN. BHD.

INN (Nama Antarabangsa):

THYROXINE SODIUM

Unit dalam pakej:

100Tablet Tablets; 200Tablet Tablets; 500Tablet Tablets

Dikeluarkan oleh:

Sriprasit Pharma Co. Ltd.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
THYROSIT TABLET
®
Thyroxine sodium (100 mcg)
1
WHAT IS IN THE LEAFLET
1.
What
_Thyrosit_
is used for
2.
How
_Thyrosit_
works
3.
Before you use
_ Thyrosit_
4.
How to use
_Thyrosit_
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
_ Thyrosit_
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
WHAT _THYROSIT_
IS USED FOR
_Thyrosit_
is used as replacement therapy to
treat thyroid hormone deficiency known as
hypothyroidism.
_Thyrosit_
is
also
used
in
conditions
where
there
is
a
shortage
of
thyroid
hormones
supply
in
the
body.
_Thyrosit_
is also used to treat goitre or chronic
lymphocytic thyroiditis, conditions in which
the thyroid gland becomes enlarged causing a
swelling in the front of the neck.
HOW _THYROSIT_
WORKS
_Thyrosit_
contains
the
active
ingredient
thyroxine
sodium,
which
is
a
thyroid
hormone. Thyroxine is an essential hormone
produced by thyroid gland in the neck. It
controls
many
bodily
functions
mainly
related to growth and energy.
BEFORE YOU USE _THYROSIT _
-
_When you must not use it_
_ _
•
Have ever had allergic reaction to thyroxine
sodium,
the
active
ingredient,
or
to
any
other ingredients in
_Thyrosit_
•
Have overactive thyroid gland
•
Subclinical
hyperthyroidism
(low
thyroid
stimulating hormone with normal thyroid
levels and not being treated)
•
Suffer from any conditions that affect your
adrenal gland and not being treated
•
Suffer from heart attack
If you are not sure whether you should start
taking this medicine, consult your doctor.
-
_Before you start to use it_
_ _
Tell your doctor if you have allergies to any
other
medicines,
foods,
preservatives
or
dyes.
Tell your doctor if you:
•
Are breast feeding or plan to breast feed
•
Suffer from any heart conditions such as
high blood pressure, chest pain (angina),
heart failure, or heart attack
•
Undergoing surgery
•
Fasting
•
Suffers
from
any
conditions
that
affects
your adrenal gland
•
Any abnormalities in thyroid

Ciri produk

4DESCRIPTION
White
round
biconvex
tablet
with
a
bisect
and
embossed with “THYROSIT”, “SPS” on one side, plain on
the other. Each tablet contains L-Thyroxine sodium
100mcg
PHARMACODYNAMIC
Thyroxine is an essential hormone that affects the rate
of
many
physiologic
processes
especially
the
metabolic rate of body tissues and the regulation of
cell growth and differentiation. Thyroxine will reverse
the
signs
and
symptoms
of
hypothyroidism
and
myxoedema
by
increasing
renal
blood
flow
and
glomerular filtration rate, resulting in a diuresis within 24
hours following administration. In hypothyroid children,
thyroxine
increases
epiphyseal
growth
and
bone
ossification. It is used to reduce goitre size by
suppressing the secretion of thyrotropin.
PHARMACOKINETICS
Following
oral
administration,
thyroxine
sodium
is
absorbed from the GI tract. The amount absorbed
increases during fasting conditions. It is distributed into
most
body
tissues
and
fluids
with
highest
concentrations in the liver and kidneys. Thyroxine does
not readily cross the placenta and minimal amounts
are secreted into milk. About one third of absorbed
thyroxine
(T4)
is
converted,
by
deiodination,
to
triiodothyronine (T3), an active metabolite. Thyroxine is
more than 99% bound to serum proteins resulting in
high
serum
concentration
and
slow
metabolic
clearance. The plasma half-life is 6-7 days and has the
advantage that it needs only be given as a single daily
dose.
About
20-40%
of
thyroxine
is
eliminated
unchanged in the faeces while 85% is metabolized
daily
through
deiodination.
Iodine
liberated
by
deiodination reaction is utilised by thyroid gland for
hormone synthesis or is excreted in faeces via bile or in
urine.
INDICATIONS
_Thyrosit 100mcg is used in the: _
_- _Treatment of hypothyroidism
- Replacement or substitution of diminished or absent
thyroid
function
resulting
from
primary
causes
including functional deficiency, primary atrophy and
partial or complete absence of the gland or from the
effects or surgery, radiation of thyroid glands.
- Repl