CLOLAR- clofarabine injection Amerika Syarikat - Inggeris - NLM (National Library of Medicine)

clolar- clofarabine injection

sanofi-aventis u.s. llc - clofarabine (unii: 762rdy0y2h) (clofarabine - unii:762rdy0y2h) - clofarabine 1 mg in 1 ml - clolar® (clofarabine) injection is indicated for the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens. this indication is based upon response rate. there are no trials verifying an improvement in disease-related symptoms or increased survival with clolar. none pregnancy category d clolar (clofarabine) may cause fetal harm when administered to a pregnant woman. clofarabine was teratogenic in rats and rabbits. developmental toxicity (reduced fetal body weight and increased post-implantation loss) and increased incidences of malformations and variations (gross external, soft tissue, skeletal and retarded ossification) were observed in rats receiving 54 mg/m2 /day (approximately equivalent to the recommended clinical dose on a mg/m2 basis), and in rabbits receiving 12 mg/m2 /day (approximately 23% of the recommended clinical dose on a mg/m2 basis). there are no adequate and well-controlled studies in pregnant women usin