PROCHLOR TABLET 5

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PROCHLORPERAZINE MALEATE

Boleh didapati daripada:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

INN (Nama Antarabangsa):

PROCHLORPERAZINE MALEATE

Unit dalam pakej:

1000 Tablet Tablets; 500 Tablet Tablets; 100 Tablet Tablets

Dikeluarkan oleh:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Risalah maklumat

_Consumer Medication Information Leaflet (RIMUP) _
1
PROCHLOR TABLET 5MG
Prochlorperazine Maleate 5mg
WHAT IS IN THE LEAFLET?
1.
What Prochlor is used for
2.
How Prochlor works
3.
Before you use Prochlor
4.
How to use Prochlor
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
Prochlor
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT PROCHLOR IS USED FOR
Prochlor
is
indicated
in
the
management
of
psychotic
conditions
including
the
treatment of schizophrenia and
for
the
quieting
effect
in
hyperactive
or
excited
psychotic patients
Prochlor is used to treat nausea,
vomiting and dizziness due to
various
causes,
including
migraine (severe headache) or
drug induced emesis (vomiting)
and
for
the
short-term
symptomatic
relief
or
vertigo
as
occurs
in
the
Meniere’s
disease (an inner ear disorder
that affects balance and hearing)
or
labyrinthitis
(irritation
and
swelling of the inner ear)
HOW PROCHLOR WORKS
Prochlor belongs to a group of
medicines
called
phenothiazines.
It
helps
to
correct chemical imbalances in
the
brain,
allowing
it
to
function
correctly.
These
chemicals may also affect the
parts of the brain which control
nausea
(feeling
sick)
and
vomiting.
BEFORE YOU USE PROCHLOR
-
_When you must not take it _
Do
not
take
Prochlor
if
you
have an allergy to:
•
Prochlor
•
severe
central
nervous
system depression
•
severe
cardiovascular
disease.
•
the
group
of
medicines
called Phenothiazines
•
of the ingredients listed at
the end of this leaflet.
Symptoms
of
an
allergic
reaction
to
Prochlor
may
include:
•
shortness
of
breath,
wheezing
or
difficulty
in
breathing
•
swelling of the face, lips,
tongue or other parts of the
body
•
rash, itching or hives on the
skin
Prochlor must not be given to
anyone who is unconscious or
in a coma.
Do not take any medicines that
cause drowsiness while you are
taking Prochlor.
Do not take this medicine after
the expiry date printed on the
pack or if the packaging is torn
or shows signs of tampering.
If you are

Ciri produk

DESCRIPTION
PHARMACOKINETICS
INDICATIONS
DOSAGE
PHARMACODYNAMICS
A 6.5 mm diameter, round, convex, scored pink tablet marked
“UP” on one side containing 5mg prochlorperazine maleate per
tablet.
Prochlor is indicated in the management of psychotic conditions
including the treatment of schizophrenia and for production of
quieting
effect
in
hyperactive
or
excited
psychotic
patients.
Prochlor can also be used to control severe nausea and vomiting
including that associated with migraine or drug induced emesis
and for the short-term symptomatic relief or vertigo as occurs in
Meniere's disease or labyrinthitis.
Prochlorperazine is a piperazine type of phenothiazine. Its antipsy-
chotic effect may be due to the blockage of postsynaptic mesolim-
bic dopaminergic receptors in the brain, which also increases
prolactin release by the pituitary. An alpha adrenergic blocking
effect is also produced which depresses the release of hypothalamic
and hypophyseal hormones.
Prochlorperazine acts centrally to inhibit or block the dopamine
(D2)
receptors
in
the
medulary
chemoreceptor
trigger
zone
(CTZ) and peripherally by blocking the vagus nerve in the gastro-
intestinal tract. Its antiemetic effect may be augmented by their
anticholinergic, sedative and antihistaminic effects.
Prochlorperazine is well absorbed from the GI tract but is subject
to considerable first pass metabolism from the gut wall. It is also
extensively metabolised in the liver and is excreted in the urine and
bile. Plasma concentrations following oral administration are
much lower than those following intramuscular injection, and are
subject to wide inter-subject variation. There is no simple correla-
tion between plasma concentrations of prochlorperazine and its
metabolites, and therapeutic effect.
Prochlorperazine
may
be
metabolised
by
hydroxylation
and
conjugation with glucuronic acid, N-oxidation, oxidation of the
sulfur atom and dealkylation. Plasma half-life is reported to be
only a few hours but elimination of the metabolites may be very
prolonged.
Proch