PRETENOL C 100 TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ATENOLOL; CHLORTHALIDONE

Boleh didapati daripada:

DUOPHARMA (M) SDN. BHD.

INN (Nama Antarabangsa):

ATENOLOL; CHLORTHALIDONE

Unit dalam pakej:

30 Tablets

Dikeluarkan oleh:

DUOPHARMA (M) SDN. BHD.

Risalah maklumat

_Consumer Medication Information Leaflet (RIMUP)_
1
PRETENOL-C TABLET
Atenolol/Chlorthalidone (50mg/12.5mg, 100mg/25mg)
WHAT IS IN THE LEAFLET?
1.
What
PRETENOL-C
TABLET is used for
2.
How
PRETENOL-C
TABLET works
3.
Before
you
use
PRETENOL-C TABLET
4.
How to use PRETENOL-C
TABLET
5.
While
you
are
using
PRETENOL-C-TABLET
6.
Side effects
7.
Storage and Disposal of
PRETENOL-C TABLET
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of Revision
WHAT
PRETENOL-C
TABLET IS USED FOR
PRETENOL-C
TABLET
is
used
to
treat
high
blood
pressure.
HOW
PRETENOL-C
TABLET WORKS
PRETENOL-C
TABLET
contains
two
different
medicines
atenolol
and
chlorthalidone.
Atenolol belongs to a group of
medicines
called
beta-
blockers. It works by making
your
heart
beat
more
slowly
and with less force.
Chlorthalidone
belongs
to
a
group
of
medicines
called
diuretics.
It
works
by
increasing the amount of urine
produced by your kidneys.
BEFORE
YOU
USE
PRETENOL-C TABLET
-
_When you must not use it_
Do
not
take
PRETENOL-C
TABLET
if
you
are allergic to
Atenolol
or
Chlorthalidone
or
any of the other ingredients listed
at the end of the leaflet.
Do
not
use
PRETENOL-C
TABLET if you:
•
Allergic
to
any
other
ingredients in your medicine.
•
Have ever had heart problems
•
Have
problems
with
your
kidneys
•
Have
a
tumour
called
pheochromocytoma
that
is
not
being
treated.
This
is
usually near your kidney and
can
cause
high
blood
pressure.
•
Have been told that you have
higher than normal levels of
acid in your blood (metabolic
acidosis).
-
_Before you start to use it_
Before
taking
PRETENOL-C
TABLET, you must tell your
doctor
or
pharmacist
if
you
have, or have had, any of the
following conditions:
•
Asthma,
wheezing
or
any
other
similar
breathing
problems or you get allergic
reactions,
for
example
to
insect stings
•
A type of chest pain (angina)
called
prinzmetal’s
angina.
Poor
blood
circulation
or
controlled heart failure
•
Have first degree heart block
•
Diabetes
•
Thyrotoxicosis
(abnormally
active thyroid gland)

Ciri produk

[DUOPHARMA (M) SDN BHD]
[Page 1/2]
[Revision Date: 12.05.2022]
PRETENOL-C 50 & -C100
DESCRIPTION: PRETENOL-C 100 TABLET: White to off-white, 9 mm round,
‘d’ marking at one side and scored on the other side, tablet
PRETENOL-C 50 TABLET: White to off-white, 7 mm round shape with
‘duo’ marking at one side and plain on the other side, tablet.
COMPOSITION: PRETENOL-C 100 TABLET: Each tablet contains Atenolol 100
mg, Chlorthalidone 25 mg
PRETENOL-C 50 TABLET: Each tablet contains Atenolol 50 mg,
Chlorthalidone 12.5 mg
PHARMACODYNAMICS: Atenolol and Chlorthalidone have been used singly
and concomitantly for the treatment of hypertension. The
antihypertensive effects of these agents are additive and studies have
shown that
there is no significant interference with bioavailability when these
agents are given together in the single combination tablet. In
patients with more severe hypertension Pretenol-C may be administered
with other
antihypertensive such as vasodilators.
ATENOLOL: A beta-adrenoreceptor blocking drug which acts
preferentially on beta-receptors in the heart. Selectivity decreases
with increasing dose. It has little intrinsic sympathomimetic activity
and no
membrane stabilising activity. Atenolol is a racemic mixture and its
activity resides in the S(-) enantiomer. It reduces raised blood
pressure by an unknown mechanism and also inhibits exercise induced
tachycardia
and decreases plasma renin concentration. It causes slight airways
obstruction but less than that seen with non-selective beta-blockers.
The inhibition of exercise induced tachycardia is correlated with
blood
levels, but there is no correlation between plasma concentrations and
antihypertensive effect. Atenolol is effective and well-tolerated in
most ethnic populations although the response may be less
Afro-Caribbean black
patients.
The possible mechanism of the anti-anginal activity of Atenolol
appears to be due to a reduction in left ventricular work and oxygen
utilisation resulting (mainly) from the decrease in heart rate and
contract