POLARINE TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PSEUDOEPHEDRINE HYDROCHLORIDE; DEXCHLORPHENIRAMINE MALEATE

Boleh didapati daripada:

SUNWARD PHARMACEUTICAL SDN. BHD.

INN (Nama Antarabangsa):

PSEUDOEPHEDRINE HYDROCHLORIDE; DEXCHLORPHENIRAMINE MALEATE

Unit dalam pakej:

1000 Tablet Tablets; 100 Tablets; 90 Tablets; 1000 Tablets; 1000 Tablets; 100 Tablets; 500 Tablets; 500 Tablets

Dikeluarkan oleh:

SUNWARD PHARMACEUTICAL SDN. BHD.

Risalah maklumat

POLARINE TABLET
Dexchlorpheniramine maleate/Pseudoephedrine hydrochloride (2mg/60mg)
_ Consumer Medication Information Leaflet (RIMUP)_
WHAT IS IN THIS LEAFLET
1. What
Polarine Tablet
is used for
2. How
Polarine Tablet
works
3. Before you use
Polarine Tablet
4. How to use
Polarine Tablet
5. While you are using it
6. Side effects
7. Storage & disposal of
Polarine Tablet
8. Product description
9. Manufacturer and Product Registration
Holder
10.Date of revision
WHAT POLARINE TABLET IS USED FOR
It is indicated for nasal and upper respiratory
tract congestion, common cold, acute sinusitis
(inflammation
of
the
sinuses)
and
allergic
rhinitis
(inflammation
of
the
mucous
membrane inside the nose).
HOW POLARINE TABLET WORKS
The active ingredients in the medicine are
Dexchlorpheniramine
maleate
and
Pseudoephedrine hydrochloride.
Dexchlor-
pheniramine maleate is anti-histamine with
anti-cholinergic properties. It works by block-
ing a certain natural substance (histamine) that
your body makes during an allergic reaction.
By blocking another natural substance made
by your body (acetylcholine), it helps dry up
some body fluids to relieve symptoms such as
watery eyes and runny nose.
Pseudoephedrine acts as an indirect sympatho-
mimetic agent by stimulating sympathetic (ad-
renergic) nerve endings to release noradrena-
line. Pseudoephedrine belongs to a class of
medications
called
nasal
decongestants.
It
works by causing narrowing of the blood ves-
sels in the nasal passages to decrease swelling
and congestion.
BEFORE YOU USE POLARINE TABLET
_- When you must not use it _
Do not take Polarine Tablet if you:

are hypersensitive to dexchlorpheniramine
maleate and pseudoephedrine hydrochlo-
ride, or any of the other ingredients listed at
the end of the leaflet.
_ _

have lower respiratory symptoms

severe high blood pressure

severe heart disease
_Pregnancy and breastfeeding _
Tell your doctor if you are or think you may
be pregnant, planning to become pregnant or
if you are breastfeeding.
_ _
_Elderly _
Antihistamines m

Ciri produk

PHARMACOLOGY:
Dexchlorpheniramine Maleate is an anti-histamine with anti-cholinergic
properties. It is capable of producing a slight to
moderate sedative effect. It appears to compete with histamine for
receptor sites on effector cells and are of value
clinically in the prevention and relief of many allergic
manifestations.It has been demonstrated that the predominant
activity of the optically active isomers of chlorpheniramine is the
dextro-isomer. The dextro-isomer is approximately two
times more active than the racemic compound. Since dexchlorpheniramine
is the dextro-isomer and active moiety of
chlorpheniramine, its action and uses are similar to those of
chlorpheniramine. Peak blood levels were achieved at an
average time of 3 hours after administration. The half life of
Dexchlorpheniramine Maleate ranged from 20 to 24 hours.
The drug when given is found to be extensively metabolized. The drug
and metabolites were primarily excreted in the
urine, with 19% of the dose appearing in 24 hours and a total of 34%
in 48 hours. Pseudoephedrine is a physiologically
active
stereoisomer
of
ephedrine
that
acts
directly
on
alpha-adrenergic
receptors
and
to
a
lesser
degree,
beta-adrenergic receptors. The alpha-adrenergic effects are believed
to result from the reduced production of cyclic
adenosine 3', 5' monophosphate (cyclic 3',5' AMP) by inhibition of the
enzyme adenyl cyclase, whereas beta-adrenergic
effects appear to be caused by the stimulation of adenyl cyclase
activity. Pseudoephedrine acts on alpha-adrenergic
receptors in the nasal mucosa and releases norepinephedrine, hence
producing vasoconstriction of the dilated nasal
arterioles resulting in shrinkage of swollen nasal mucous membranes,
reduction of tissue hyperemia, oedema and nasal
decongestion and an increase in nasal airway patency. Drainage of
sinus secretions is increased and obstructed
eustachian ostia may be opened. Relaxation of bronchial smooth muscle
by stimulation of beta-adrenergic receptors
may also occur. Following oral administration of 30 mg o