PENICILLIN V POTASIUM tablet

Country: Amerika Syarikat

Bahasa: Inggeris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

PENICILLIN V POTASSIUM (UNII: 146T0TU1JB) (PENICILLIN V - UNII:Z61I075U2W)

Boleh didapati daripada:

RedPharm Drug, Inc.

INN (Nama Antarabangsa):

PENICILLIN V POTASSIUM

Komposisi:

PENICILLIN V 500 mg

Laluan pentadbiran:

ORAL

Jenis preskripsi:

PRESCRIPTION DRUG

Tanda-tanda terapeutik:

Penicillin V potassium tablets are indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with penicillin V during the acute stage. Indicated surgical procedures should be performed. The following infections will usually respond to adequate dosage of penicillin V. Streptococcal Infections (without bacteremia) Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. NOTE: Streptococci in groups A, C, G, H, L, and M are very sensitive to penicillin. Other groups, including group D (enterococcus), are resistant. Pneumococcal Infections Mild to moderately severe infections of the respiratory tract. Staphylococcal infections – penicillin G-sensitive Mild infections of the skin and soft tissues. NOTE: Reports

Ringkasan produk:

Penicillin-VK Tablets (Penicillin V Potassium Tablets USP), 250 mg (400,000 units) are round, biconvex white tablets, debossed PVK 250 and break scored on one side and GG 949 on the reverse side. NDC 0781-1205-01 bottles of 100 NDC 0781-1205-10 bottles of 1000 Penicillin-VK Tablets (Penicillin V Potassium Tablets USP), 500 mg (800,000 units) are oblong, biconvex white tablets, debossed PVK 500 on one side and GG 950 on the reverse side and break scored on both sides. NDC 0781-1655-01 bottles of 100 NDC 0781-1655-10 bottles of 1000 Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature). Keep tightly closed. Dispense in a tight container, as defined in the USP. REFERENCES 1. American Heart Association.1984. Prevention of bacterial endocarditis. Circulation 70(6):1123A –1127A. 2. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial DiskSusceptibility Test; Approved Standard-Eleventh Edition. CLSI document M02-A11. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012. 3. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Test for Bacteria That Grow Aerobically; Approved Standard-Ninth Edition. CLSI document M07-A9. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012. 4. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. CLSI document M100-S22. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.

Status kebenaran:

Abbreviated New Drug Application

Ciri produk

PENICILLIN V POTASIUM- PENICILLIN V POTASIUM TABLET
REDPHARM DRUG, INC.
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PENICILLIN VK 500MG
SPL UNCLASSIFIED SECTION
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of penicillin-VK
and other antibacterial drugs, penicillin-VK should be used only to
treat or prevent infections that are
proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Penicillin V is the phenoxymethyl analog of penicillin G.
Penicillin V potassium is the potassium salt of penicillin V.
[Penicillin V Potassium Chemical Structure]
Molecular Formula: C16H17O5KN2S Molecular Weight: 388.5
Penicillin -VK (Penicillin V Potassium Tablets USP), for oral
administration, contain 250 mg (400,000
units) or 500 mg (800,000 units) penicillin V. In addition, each
tablet contains the following inactive
ingredients: hydroxypropyl methylcellulose, magnesium stearate,
polyethylene glycol, povidone, talc,
and titanium dioxide.
CLINICAL PHARMACOLOGY
Penicillin V exerts a bactericidal action against penicillin-sensitive
microorganisms during the stage of
active multiplication. It acts through the inhibition of biosynthesis
of cell-wall mucopeptide. It is not
active against the penicillinase-producing bacteria, which include
many strains of staphylococci. The
drug exerts high in vitro activity against staphylococci (except
penicillinase-producing strains),
streptococci (groups A, C, G, H, L and M), and pneumococci. Other
organisms sensitive in vitro to
penicillin V are Corynebacteriumdiphtheriae, Bacillus anthracis,
Clostridia,
Actinomycesbovis,Streptobacillusmoniliformis, Listeria monocytogenes,
Leptospira, and Neisseria
gonorrhoeae.Treponemapallidum is extremely sensitive.
The potassium salt of penicillin V has the distinct advantage over
penicillin G in resistance to
inactivation by gastric acid. It may be given with meals; however,
blood levels are slightly higher when
the drug is given on an empty stomach. Average blood levels are two to
five times higher than the
levels following the same dose of oral