PANTOR 40MG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PANTOPRAZOLE SODIUM SESQUIHYDRATE

Boleh didapati daripada:

LABORATORIES TORRENT (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

PANTOPRAZOLE SODIUM SESQUIHYDRATE

Unit dalam pakej:

10 Tablet Tablets; 100 Tablet Tablets; 30 Tablet Tablets

Dikeluarkan oleh:

TORRENT PHARMACEUTICALS LTD.

Risalah maklumat

PANTOR TABLET
_ _
Pantoprazole sodium sesquihydrate (20 mg, 40 mg)
_ _
_ _
1
_ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What is Pantor used for
2.
How Pantor works
3.
Before you use Pantor
4.
How to use Pantor
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Pantor
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
11.
Serial Number
WHAT PANTOR IS USED FOR
Pantor 40 is indicated for the short term
treatment
of
duodenal
ulcer,
gastric
ulcers
and
reflux
esophagitis
(inflammation
of
the
oesophagus
(a
tube that runs from the throat to the
stomach)
accompanied
by
the
regurgitation of stomach acid). If the
duodenal ulcer has been demonstrated
to
be
associated
with
_Helicobacter _
_pylori_
(bacteria)
infection,
Pantor
40
used in combination with appropriate
antibiotics may be useful.
Pantor 20 is indicated for symptomatic
treatment improvement (e.g. heartburn,
acid regurgitation, pain on swallowing)
and healing of mild gastro- esophageal
reflux disease (GERD) caused by reflux
of acid from the stomach.
Pantor 20 is indicated for long term
management and prevention of relapse
in Gastro Esophageal Reflux Disease
(GERD).
HOW PANTOR WORKS
Pantoprazole
is
a
selective
“proton
pump inhibitor”. Pantoprazole belongs
to
a
group
known
as
substituted
benzimidazole which stop the secretion
of
gastric
acid
in
the
stomach
by
specific blockade of the proton pumps
of the parietal cells.
BEFORE YOU USE PANTOR
-
_When you must not use it _
Do not take Pantor:
•
If you are allergic (hypersensitive)
to pantoprazole or to any of the
other ingredient of Pantor.
•
If you have severe liver disease.
Your doctor will check your liver
enzymes
more
frequently,
especially
when
you
are
taking
Pantor as a long term treatment.
Prior to treatment, the possibility of
a life-threatening gastric ulcer or a
life-threatening oesophagus disease
should be excluded. Diagnosis of
reflux
oesophagitis
will
be
confirmed by endoscopy (used for
examination of digest

Ciri produk

xxxxxxxx-5253
COMPOSITION:
PANTOR 20
Each enteric-coated tablet contains:
Pantoprazole sodium sesquihydrate equivalent to
Pantoprazole 20 mg
Colours: Yellow Oxide of Iron & Titanium Dioxide
PANTOR 40
Each enteric-coated tablet contains:
Pantoprazole sodium sesquihydrate equivalent to
Pantoprazole 40 mg
Colours: Yellow Oxide of Iron & Titanium Dioxide
PHARMACOLOGICAL ACTION:
SITE AND MECHANISM OF ACTION/ PHARMACODYNAMIC
Pantoprazole is a proton pump inhibitor, i.e., it inhibits
specifically and dose proportionally H+,K+-ATPase, the enzyme which is
responsible for gastric acid secretion in the parietal cells of the
stomach.
Pantoprazole is a substituted benzimidazole which accumulates in the
acidic compartment of the parietal cells after absorption. In the
parietal cell it is protonated and chemically re-arranged to the
active inhibitor, a cyclic sulphenamide, which binds to the
H+,K+-ATPase, thus inhibiting the proton pump and causing suppression
of stimulated and basal gastric acid secretion after single
and multiple intravenous and oral pantoprazole dosing. Because
pantoprazole acts distal to the receptor level, it can influence
gastric
acid secretion irrespective of the nature of the stimulus.
Pantoprazole exerts its full effect in a strongly acidic environment
(pH<3) and remains mostly inactive at higher pH values, which
explains its selectivity for the acid secreting parietal cells of the
stomach. Therefore, the complete pharmacological and therapeutic
effect for pantoprazole can only be achieved in the acid-secreting
parietal cells. By means of a feedback mechanism this effect is
diminished at the same rate as acid secretion is inhibited.
EFFECT ON GASTRIC ACID SECRETION
The mean inhibition of pentagastrin stimulated acid output after 40
mg/day is 85% after seven days, 2½ to 3½ hours after dosing. After
stopping the intake of pantoprazole, there is no evidence of rebound
hypersecretion and 7 days after taking the last dose, the acid
output is normal.
Pantoprazole maintains the physiological pH-rhythm. The