Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CLOXACILLIN SODIUM
DUOPHARMA (M) SDN. BHD.
CLOXACILLIN SODIUM
500 Capsules; 1000 Capsules
DUOPHARMA (M) SDN. BHD.
OXACIL CAPSULE Cloxacillin Sodium (250mg) 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Cloxacillin Capsule is used for 2. How Cloxacillin Capsule works 3. Before you use Cloxacillin Capsule 4. How to use Cloxacillin Capsule 5. While you are using it 6. Side effects 7. Storage and Disposal of Cloxacillin Capsule 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT CLOXACILLIN CAPSULE IS USED FOR Cloxacillin Capsule is used to treat a wide variety of bacterial infections. HOW CLOXACILLIN CAPSULE WORKS This medication is a type of penicillin antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). BEFORE YOU USE CLOXACILLIN CAPSULE - _When you must not use it _ Before taking cloxacillin, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics including penicillin-type medications (e.g., amoxicillin, ampicillin, penicillin) or cephalosporins (e.g., cephalexin, cefuroxime); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. _ _ _Pregnancy and lactation _ Do not take Cloxacillin Capsule if you are pregnant, trying to get pregnant or think you may be pregnant. Do not take Cloxacillin Capsule if you are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine. - _Before you start use it _ Before using this medication, tell your doctor or pharmacist your medical history, especially of kidney problems. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug. Kidney function is not fully developed in newborns. This medication is removed by the kidneys. Therefore, newborns may be more sensitive to this drug. This medication should be used only when clearly needed Baca dokumen lengkap
[DUOPHARMA (M) SDN BHD] [Page 1/2] [Revision date: 7.2.2022] OXACIL DESCRIPTION: Oxacil Capsule 250mg : A size 2, scarlet/grey, marked ‘CLOX/250’ capsule. Oxacil Granules 125mg/5ml : An almost white powder when reconstituted forms a yellow, fruity flavoured, homogenous suspension. COMPOSITION: Oxacil Capsule 250mg : Each capsule contains Cloxacillin 250 mg. Oxacil Granules 125mg/5ml : Each 5 mL contains Cloxacillin 125 mg. Preservative: Sodium Benzoate 0.2% PHARMACODYNAMICS: Cloxacillin is an isoxazolyl penicillin and is resistant to staphylococcal penicillinase. It exerts its killing action on gro wing and dividing bacteria by inhibiting bacterial cell wall synthesis. Bacterial cell walls are held rigid and protected against osmotic rupture by peptidoglycan. Cloxacillin inhibits the final cross-linking stage of peptidoglycan production by binding to and inactivating transpeptidases, penicillin-binding proteins on the inner surface of the bacterial cell membrane. Other mechanisms involved include bacterial lysis by the inactivation of endogenous inhibitors of bacterial autolysins. PHARMACOKINETICS: Cloxacillin sodium is incompletely absorbed from the gastrointestinal tract following oral administration, and absorption is further reduced by the presence of food. Peak plasma concentrations of 7-1 4 mcg/mL have been observed 1-2 hours after a dose of 500 mg. Doubling the dose can double the plasma concentration. Cloxacillin is widely distributed to most tissues and body fluids, including peritoneal fluid, blister fluid, urine, pleural fluid, middle ear fluid, intestinal mucosa, bone, gallbladder, lung, female reproductive tissues and bile. Distribution into the cerebrospinal fluid is low in subjects with non- inflamed meninges. Therapeutic concentrations can be achieved in pleural and synovial fluids and in bone. Cloxacillin crosses the placenta and is excreted in breast milk. About 94% of cloxacillin is bound to p lasma proteins. It has a half-life of 0.5-1 hour, and is prolonged in neonates. Thirty percent of Baca dokumen lengkap