Nolvadex & Nolvadex D

Country: Australia

Bahasa: Inggeris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Tamoxifen citrate

Boleh didapati daripada:

AstraZeneca Pty Ltd

Kelas:

Medicine Registered

Risalah maklumat

NOLVADEX
®

_Tamoxifen citrate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
In this leaflet, NOLVADEX means
Nolvadex or Nolvadex-D tablets.
This leaflet answers some of the
common questions people ask about
NOLVADEX. It does not contain all
the information that is known about
NOLVADEX.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor will have
weighed the risks of you taking
NOLVADEX against the benefits
they expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT NOLVADEX IS
FOR
NOLVADEX is used to treat breast
cancer.
NOLVADEX blocks the actions of
oestrogen. Oestrogen is a natural
female sex hormone. In some types
of breast cancer, oestrogen can help
cancer cells to grow.
Your doctor will have explained why
you are being treated with
NOLVADEX and told you what dose
to take.
FOLLOW ALL DIRECTIONS GIVEN TO YOU
BY YOUR DOCTOR.
They may differ from the
information contained in this leaflet.
Your doctor may prescribe this
medicine for another use. Ask your
doctor if you want more information.
NOLVADEX is not addictive.
BEFORE YOU USE
NOLVADEX
_WHEN YOU MUST NOT USE IT_
DO NOT USE NOLVADEX IF YOU ARE
PREGNANT, TRYING TO BECOME
PREGNANT OR ARE BREASTFEEDING.
We do not know if it is safe for you
to take it while you are pregnant. It
may affect your baby if you take it at
any time during pregnancy.
Your baby may take in NOLVADEX
from breast milk if you are
breastfeeding.
Do not use NOLVADEX if you are
allergic to tamoxifen or any of the
other ingredients in NOLVADEX.
DO NOT GIVE NOLVADEX TO
CHILDREN.
There is no experience of its use in
children.
DO NOT TAKE AFTER THE USE BY
(EXPIRY) DATE PRINTED ON THE PACK.
It may have no effect at all, or worse,
an entirely unexpected effect if you
take it after the expiry date.
DO NOT TAKE NOLVADEX IF THE
PACKAGING IS TORN OR SHOWS SIGNS OF
TAMPERING.
DO NOT U

Ciri produk

NOLVADEX Product Information 
ONC.000-313-413.9.0 
1(8) 
NOLVADEX
®

tamoxifen 
PRODUCT INFORMATION 
NAME OF THE MEDICINE 
Tamoxifen citrate. 

C
26
H
29
NO
,
C
6
H
8
O
7 
    MW: 563.6       
CAS No: _54965-24-1_ 
DESCRIPTION 
NOLVADEX (tamoxifen) is the trans-isomer
of 1-[4-(2-dimethylaminoethoxy) 
phenyl]-1,2-diphenyl-1-butene. 
NOLVADEX (tamoxifen) is a non-steroidal,
triphenylethylene-based drug which 
displays a complex spectrum
of oestrogen antagonist and oestrogen agonist-like 
pharmacological effects in different tissues.  In breast cancer
patients, at the 
tumour level, tamoxifen acts primarily as
an antioestrogen, preventing oestrogen 
binding to the oestrogen receptor.   
PHARMACOLOGY 
PHARMACOKINETICS 
_ABSORPTION _
Tamoxifen is absorbed from the gastrointestinal
tract.  However, the site and 
extent of absorption is not known.  Peak serum levels
of 15 to 25 nanogram/mL 
were observed three to six hours
after administration of a single oral dose of 10 
mg tamoxifen.  Steady state serum levels are achieved after
approximately 4 
weeks therapy.  Mean steady state values after
dosing at 20 mg twice daily were 
285 ± 19 nanogram/mL and 477 ± 35 nanogram/mL for
tamoxifen and N-
desmethyltamoxifen respectively.  
_BIOAVAILABILITY _
No information available. 
NOLVADEX Product Information 
ONC.000-313-413.9.0 
2(8) 
_DISTRIBUTION _
Little information is available in humans.  It has
been found in the uterus and 
ovary, particularly in the endometrium and corpus
luteum.  Radioactivity studies in 
animals show high levels in the liver,
lung, ovary and spleen.  Low levels have 
been found in the pituitary, eyes and brain. 
_PROTEIN BINDING _
The drug appears
to be bound to an unknown degree to cytoplasmic protein 
receptors in all oestrogen target tissues, and is
highly protein bound to ser