MUSAFEN TABLET 10MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

BACLOFEN

Boleh didapati daripada:

DUOPHARMA (M) SDN. BHD.

INN (Nama Antarabangsa):

BACLOFEN

Unit dalam pakej:

5 x 10 Tablets

Dikeluarkan oleh:

DUOPHARMA (M) SDN. BHD.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
1
MUSAFEN TABLET 10MG
Baclofen (10mg)
WHAT IS IN THE LEAFLET
1.
What MUSAFEN is used
for
2.
How MUSAFEN works
3.
Before
you
use
MUSAFEN
4.
How to use MUSAFEN
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
MUSAFEN
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of Revision
WHAT MUSAFEN IS USED FOR
MUSAFEN
is
used
to
treat
muscle
spasms
that
occur
in
various
illnesses
such
as
multiple sclerosis, disease and
injuries
of
the
spinal
cord.
MUSAFEN is not indicated for
muscle
spasms
arise
from
Parkinson’s disease or stroke.
HOW MUSAFEN WORKS
MUSAFEN belongs to a group
of
medicines
called
muscle
relaxants.
These
medicines
reduce excess tension in your
muscles that cause spasms and
pain.
Reducing
these
spasms
may
help
to
increase
your
mobility
and
make
everyday
activities easier to manage.
Your
doctor
may
have
prescribed
this
medicine
for
another reason.
Ask your doctor if you have
any questions about why it has
been prescribed for you.
BEFORE YOU USE MUSAFEN
- _When you must not use it _
_ _
Do not take this medicine if
you have an allergy to:

Baclofen,
the
active
ingredient

Any
of
the
other
ingredients listed at the end
of this leaflet
Do not take this medicine after
the expiry date printed on the
pack or if the packaging is torn
or shows signs of tampering.
If it has expired or is damaged,
return it to your pharmacist for
disposal.
If you are not sure whether you
should
start
taking
this
medicine, talk to your doctor.
-
_Before you start to use it _
_ _
Tell your doctor if you have
allergies
to
any
other
medicines, foods, preservatives
or dyes.
Tell
your
doctor
if
you
are
pregnant
or
plan
to
become
pregnant or are breastfeeding.
Your doctor can discuss with
you
the
risks
and
benefits
involved.
Tell your doctor if you have
any
of
the
following
health
problems:

Epilepsy or fits

Mental illness

Stomach ulcer

Kidney disease

Liver disease

Lung or breathing problems
If
you
have
not
told
yo

Ciri produk

[DUOPHARMA (M) SDN BHD]
MUSAFEN TABLET 10 MG
DESCRIPTION:
MUSAFEN TABLET 10 MG: A round 7 mm diameter yellow tablet with
markings "DUOMA/DUOMA" and "d".
COMPOSITION:
Each tablet contains Baclofen 10 mg.
PHARMACODYNAMICS:
The precise mechanism of action of baclofen has not been fully
determined. It acts mainly at the spinal cord level to inhibit the
transmission of both monosynaptic and polysynaptic reflexes,
possibly by hyperpolarization of primary afferent fiber terminals
resulting in antagonism of the release of putative excitatory
transmitters (i.e. glutamic and aspartic acids). Actions at
supraspinal sites may also be involved.
Baclofen is an effective antispastic agent with a spinal site of
action. Its mechanism of action and pharmacological properties are
different from those of other antispastic agents.
Baclofen depresses monosynaptic and polysynaptic reflex transmission,
probably by various actions, including stimulation of GABAB-receptors.
This stimulation in turn inhibits the release of
excitatory amino acids (glutamate and aspartate) in guinea pig
preparations. Neuromuscular transmission is not affected by baclofen.
Baclofen exerts an antinociceptive effect. The clinical significance
of this awaits clarification. In neurological diseases associated with
spasm of the skeletal muscles, the clinical effects of
Baclofen take the form of a beneficial action on reflex muscle
contractions and of marked relief from painful spasm, automatism, and
clonus. Baclofen, where indicated, improves the
patient's mobility, making for greater independence, and facilitating
passive and active physiotherapy. Baclofen stimulates gastric acid
secretion.
PHARMACOKINETICS:
Baclofen is rapidly and completely absorbed from the gastrointestinal
tract. Maximum concentrations of unchanged drug are attained in plasma
in 2 to 4 hours after an oral dose.
The distribution volume of baclofen amounts to 0.7 litre/kg. In
cerebrospinal fluid the active substance attains concentrations
approx. 8.5 times lower than in plasma.
The plasma elimi