Miniten 25mg Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

CAPTOPRIL

Boleh didapati daripada:

MEDIDATA SDN BHD

INN (Nama Antarabangsa):

CAPTOPRIL

Unit dalam pakej:

20Tablet Tablets; 100 Tablet Tablets; 1000 Tablet Tablets

Dikeluarkan oleh:

United Pharmaceutical Company Mfg. Co. Ltd.

Risalah maklumat

PATIENT INFORMATION LEAFLET
MINITEN 25MG TABLET
CAPTOPRIL 25MG TABLET
WHAT IS IN THIS LEAFLET

What is MINITEN used for

How MINITEN
works

Before you take/ How to take
MINITEN

While you are using MINITEN

Side effects

Storage and Disposal of
MINITEN

Product Description
WHAT MINITEN IS USED FOR
Miniten is used in the treatment of:
-
High blood pressure
-
Congestive heart failure
-
Heart attack
-
Kidney
failure
in
insulin
dependent
diabetes
(diabetic
kidney disease).
HOW MINITEN WORKS
MINITEN
(Captopril)
is
an
angiotensin
coverting
enzyme
(ACE)
inhibitor
which
works
by
widening
the
blood
vessels,
making it easier for the heart to pump blood
through them
BEFORE YOU TAKE MINITEN
WHEN YOU MUST NOT TAKE IT
-
If you have allergy to Captopril or
to other drugs of the same class
(conversion enzyme inhibitor).
-
During pregnancy of breastfeeding.
-
If
you
are
also
taking
certain
diuretics
(“water
tablets”)
Potassium salts or Lithium, unless
otherwise
decided
by
your
physician.
-
In
case
of
stenosis
(abnormal
narrowing or contraction of a duct
or canal) of both renal arteries and
when only one kidney is present,
unless otherwise decided by your
physician.
-
In
case
of
hyperkalaemia
(high
blood
levels
of
potassium
which
can cause muscle weakness,
twitching
or
abnormal
heart
rhythm), unless otherwise decided
by your physician.
BEFORE YOU START TO TAKE IT
You must tell your doctor is you:
-
Suffer from kidney disease,
-
Suffer from liver disease,
-
Are undergoing dialysis
-
Suffer
from
heart
disease,
in
particular
problems
with
the
valves of the heart.
-
Have diabetes,
-
Have
recently
suffered
from
excessive vomiting or diarrhea,
-
Are receiving immune-suppressant
therapy,
TAKING OTHER MEDICINES
To
avoid
interaction
with
other
drugs,
inform
your
doctor
or
pharmacist
of
any
other
other
medicines
you
are
taking,
especially
Lithium,
potassium
salts
or
diuretics.
HOW TO TAKE MINITEN
HOW MUCH TO TAKE
Follow the directions given by your doctor
or pharmacist.
-
High
blood
pressure:
The
recommended
dose
of

Ciri produk

MINITEN
25MG TABLET
Captopril, 25mg Tablet
PRODUCT DESCRIPTION
White square shape crossed tablets.
PHARMACODYNAMIC
MINITEN
(Captopril) is an angiotensin converting enzyme (ACE) inhibitor with
antihypertensive and vasodilating effects.
PHARMACOKINETICS
●
Captopril is an orally active agent that does not require
biotransformation for activity.
●
The average minimal absorption is approximately 75%. The presence of
food in the gastrointestinal tract reduces absorp-
tion by about 30-40%. Approximately 25-30% of the circulating drug is
bound to plasma proteins.
●
The apparent elimination half-life of unchanged Captopril in blood is
about 2 hours. Greater than 95% of the absorbed
dose is eliminated in the urine within 24 hours.
●
Therefore, in patients with impaired renal function the dose should be
reduced and/or dosage interval prolonged.
INDICATION
●
Hypertension: Administered alone or combined with thiazide diuretics.
The blood pressure lowering effects of captopril
and thiazides are approximately additive.
●
Congestive heart failure: In combination with a diuretic and when
appropriate, digitalis and β-blockers.
●
Myocardial infarction (MI) : In clinically stable patients with
asymptomatic and symptomatic left ventricular dysfunction
following MI.
●
Diabetic nephropathy: In patients with type-I Insulin dependent
diabetes mellitus. In these patients, captopril prevents the
progression of renal disease and reduces associated clinical sequelae
(dialysis, renal transplantation and death)
RECOMMENDED DOSE
MINITEN
should be taken one hour before meals. Dosage must be individualized.
Hypertension: Initiation of therapy requires consideration of recent
antihypertensive drug treatment, the extent of blood
pressure elevation, salt restriction, and other clinical
circumstances. If possible, discontinue the patient’s previous
antihy-
pertensive drug regimen for one week before starting
MINITEN
.
The initial dose of
MINITEN
is 50 mg once daily or 25 mg bid. If satisfactory reduction of blood
pressure has not b