MINIPRESS TABLET

Country: Kanada

Bahasa: Inggeris

Sumber: Health Canada

Bahan aktif:

PRAZOSIN (PRAZOSIN HYDROCHLORIDE)

Boleh didapati daripada:

AA PHARMA INC

Kod ATC:

C02CA01

INN (Nama Antarabangsa):

PRAZOSIN

Dos:

1MG

Borang farmaseutikal:

TABLET

Komposisi:

PRAZOSIN (PRAZOSIN HYDROCHLORIDE) 1MG

Laluan pentadbiran:

ORAL

Unit dalam pakej:

100/500

Jenis preskripsi:

Prescription

Kawasan terapeutik:

ALPHA-ADRENERGIC BLOCKING AGENTS

Ringkasan produk:

Active ingredient group (AIG) number: 0111527001; AHFS:

Status kebenaran:

APPROVED

Tarikh kebenaran:

2016-11-03

Ciri produk

PRESCRIBING INFORMATION
PRODUCT MONOGRAPH
PR
MINIPRESS
PRAZOSIN HYDROCHLORIDE TABLETS BP
TABLETS 1.0, 2.0 AND 5.0 MG
ANTIHYPERTENSIVE
AA Pharma Inc.
1165 Creditstone Road Unit #1
Vaughan, Ontario
L4K 4N7
Date of Revision:
February 19, 2021
Control No. 248447
2
PR
MINIPRESS
TABLETS 1.0, 2.0 AND 5.0 MG
Prazosin Hydrochloride Tablets BP
THERAPEUTIC CLASSIFICATION
Antihypertensive
ACTIONS AND CLINICAL PHARMACOLOGY
MINIPRESS is a formulation of prazosin hydrochloride and is a
conventional release formulation.
Prazosin causes a decrease in total peripheral resistance. Animal
studies suggest that the vasodilator
effect of prazosin is related to selective blockade of post-synaptic
alpha
1
- adrenoceptors. The results
of dog forelimb experiments demonstrate that the peripheral
vasodilator effect is confined mainly to
the level of the resistance vessels (arterioles). Hemodynamic studies
have been carried out in man
following acute single dose administration and during the course of
long term maintenance therapy.
The results confirm that the therapeutic effect is a fall in blood
pressure unaccompanied by a clinically
significant change in heart rate, renal blood flow and glomerular
filtration rate. In patients with
hypertension there is little change in cardiac output. In addition,
clinical pharmacology studies have
shown that both prazosin and prazosin GITS antagonize the vasopressor
effect of intravenous
phenylephrine, an alpha
1
-agonist.
In man blood pressure is lowered in both the supine and standing
positions. The hypotensive effect of
prazosin hydrochloride is greater when the patient is standing, and a
mild reflex tachycardia can
result. Tolerance has not been observed to develop in long term
hypertensive therapy. Rebound
elevation of blood pressure does not seem to occur following abrupt
cessation of therapy with
MINIPRESS.
Following oral administration of MINIPRESS in normal volunteers and
hypertensive patients, plasma
concentrations reach a peak at about 3 hours with a plasma half-life
of 2-3 hours. The drug is h