METOLOC 100mg Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

METOPROLOL TARTRATE

Boleh didapati daripada:

Noripharma Sdn. Bhd.

INN (Nama Antarabangsa):

METOPROLOL TARTRATE

Unit dalam pakej:

500 Tablets; 50 Tablets; 10 Tablets; 300 Tablets; 100 Tablets; 1000 Tablets

Dikeluarkan oleh:

Noripharma Sdn. Bhd.

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP) _
METOLOC 100MG TABLET
Metoprolol Tartrate 100mg
1
WHAT IS IN THIS LEAFLET?
1.
What METOLOC used for
2.
How METOLOC works
3.
Before you use METOLOC
4.
How to use METOLOC
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of METOLOC
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision.
WHAT METOLOC USED FOR
METALOC is used against:
• high blood pressure and to prevent
coronary heart disease (angina pectoris)
• Some rapid heart beat symptoms
•`Some disturbances of heart rate
(arrhythmia)
• Increased metabolic rate (thyreotoxicosis).
METALOC reduces the risk for death and
of developing another heart attack in
patients who had a heart attack. METALOC
can also be given as preventive treatment of
migraine.
HOW METOLOC WORKS
Metoprolol reduces the effect of stress
hormones in the heart in connection with
physical or mental effort. It makes the heart
beat slower (reduces pulse) in these
situations. The reduced cardiac work also
prevents onset of angina.
BEFORE YOU USE METOLOC
-_WHEN YOU MUST NOT USE IT_
Do not use METALOC if you have:
• Untreated heart failure
• Serious heart block and/or very low pulse
• Very low blood pressure.
• Do not use METALOC if you are
hypersensitive to any of the ingredients or
to other similar drugs (beta-receptor
blocking drugs)
_- BEFORE YOU START TO USE IT _
Talk to your doctor before you start using
METALOC if you have any of the
following diseases:
• asthma
• severe symptoms of narrow airways
• Serious problems with metabolism
(metabolic acidosis)
• Prinzmetal’s angina
• Severely impared kidney function.
If you suffer from impared blood
circulation, in your hands, feet, arms or legs
(claudication), symptoms may worsen from
the METALOC medication.
_-TAKING OTHER MEDICINES _
Tell your doctor if you are using other
medicines when taking METALOC. Some
medicines can affect or be affected by the
treatment with METALOC, for example:
• propafenone, amiodarone, quini

Ciri produk

1
METOLOC 100MG TABLET
COMPOSITION
Each tablet contains Metoprolol Tartrate 100mg
PRODUCT DESCRIPTION
A white round shaped tablet with score line on one side.
_(The tablet is not meant to be split ) _
PHARMACODYNAMICS
Metoprolol is a beta1-selective receptor blocker, i.e. metoprolol
affects the beta1-receptors of the
heart in lower doses than needed to affect beta2-receptors in
peripheral vessels and bronchi. At
increasing doses the beta1-selectivity may decrease.
Metoprolol has no beta-stimulating effect and has little
membrane-stimulating effect. Beta
receptor blockers have negative inotropic and chronotropic effect.
Metoprolol therapy reduces the effect of catecholamines in association
with physical and psychic
strain and gives lower heart rate, cardiac output and blood pressure.
In stress situations with an
increased release of adrenaline from the adrenal glands, metoprolol
does not prevent the normal
physiological vascular dilation. In therapeutic doses, metoprolol has
less contractile effect on the
bronchial muscles than non-selective beta-blockers. This property
enables treatment of patients
with bronchial asthma or other pronounced obstructive lung diseases
with metoprolol in
combination with beta2-receptor stimulants. Metoprolol influences
insulin release and
carbohydrate metabolism to less extent than non-selective
beta-blockers and therefore it can also
be given to patients with diabetes mellitus. The cardiovascular
reaction in hypoglycaemia, e.g.
tachycardia, is less influenced by metoprolol and the return of blood
sugar level to normal is faster
than for non-selective beta-receptor blockers.
In hypertension, Metoloc lowers the blood pressure significantly for
more than 24 hours both in
lying and standing positions as well as during exercise. In treatment
with metoprolol an increase in
the peripheral vascular resistance is observed initially. In long-term
treatment, however, the
obtained lowering in blood pressure may be due to reduced peripheral
vascular resistance and
unchanged cardiac output. In ma