METOLAZONE tablet

Country: Amerika Syarikat

Bahasa: Inggeris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

metolazone (UNII: TZ7V40X7VX) (metolazone - UNII:TZ7V40X7VX)

Boleh didapati daripada:

Avera McKennan Hospital

INN (Nama Antarabangsa):

metolazone

Komposisi:

metolazone 2.5 mg

Jenis preskripsi:

PRESCRIPTION DRUG

Status kebenaran:

New Drug Application Authorized Generic

Ciri produk

METOLAZONE- METOLAZONE TABLET
AVERA MCKENNAN HOSPITAL
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METOLAZONE TABLETS, USP
Rx Only
DO NOT INTERCHANGE
DO NOT INTERCHANGE UPSTATE'S METOLAZONE TABLETS, USP, ZAROXOLYN®
TABLETS, AND OTHER FORMULATIONS OF METOLAZONE THAT SHARE THEIR
SLOW AND INCOMPLETE BIOAVAILABILITY AND ARE NOT THERAPEUTICALLY
EQUIVALENT AT THE SAME DOSES TO MYKROX® TABLETS, A MORE RAPIDLY
AVAILABLE AND COMPLETELY BIOAVAILABLE METOLAZONE PRODUCT.
FORMULATIONS BIOEQUIVALENT TO ZAROXOLYN AND FORMULATIONS
BIOEQUIVALENT TO MYKROX SHOULD NOT BE INTERCHANGED FOR ONE
ANOTHER.
DESCRIPTION
Upstate's metolazone tablets, USP, for oral administration contain
2½, 5, or 10 mg of metolazone, USP, a
diuretic/saluretic/antihypertensive drug of the quinazoline class.
Metolazone has the molecular formula C
H ClN O S, the chemical name 7-chloro-1, 2, 3, 4-
tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide,
and a molecular weight of
365.83. The structural formula is:
Metolazone is only sparingly soluble in water, but more soluble in
plasma, blood, alkali, and organic
solvents.
Inactive Ingredients: Magnesium stearate, microcrystalline cellulose
and dye: 2½ mg-D&C Red No. 33;
5 mg-FD&C Blue No. 2; 10 mg-D&C Yellow No. 10 and FD&C Yellow No. 6.
CLINICAL PHARMACOLOGY
Metolazone is a quinazoline diuretic, with properties generally
similar to the thiazide diuretics. The
actions of metolazone result from interference with the renal tubular
mechanism of electrolyte
reabsorption. Metolazone acts primarily to inhibit sodium reabsorption
at the cortical diluting site and to
a lesser extent in the proximal convoluted tubule. Sodium and chloride
ions are excreted in
approximately equivalent amounts. The increased delivery of sodium to
the distal tubular exchange site
results in increased potassium excretion. Metolazone does not inhibit
carbonic anhydrase. A proximal
action of metolazone has been shown in humans by increased excretion
of phosphate and magnesium
ions and by a markedly increased fractional excretion of sodium in
patients with se