METOHEXAL 100 TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

METOPROLOL TARTRATE

Boleh didapati daripada:

IMEKS PHARMA SDN. BHD.

INN (Nama Antarabangsa):

METOPROLOL TARTRATE

Unit dalam pakej:

20 Tablets; 50 Tablets; 100 Tablets; 100 Tablets

Dikeluarkan oleh:

Salutas pharma GmbH

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
METOHEXAL TABLET
Metoprolol Tartrate (50mg, 100mg)
WHAT IS IN THIS LEAFLET
1.
What Metohexal is used for
2.
How Metohexal works
3.
Before you use Metohexal
4.
How to use Metohexal
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Metohexal
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of revision
WHAT METOHEXAL IS USED FOR
This medicine is used:
• To treat high blood pressure (hypertension)
• In management of heart attack (myocardial
infarction)
• To treat irregular heart beat (arrhythmia)
• To treat coronary artery disease (narrowing
of blood vessels)
HOW METOHEXAL WORKS
Metohexal contains active ingredient,
metoprolol that belongs to the group of
medicines called beta blockers.
It works by affecting the body's response to
some nerve impulses, especially in the heart.
As a result, it decreases the heart's need for
blood and oxygen and therefore reduces the
amount of work the heart has to do.
It also widens the blood vessels in the body,
causing blood pressure to fall.
BEFORE YOU USE METOHEXAL_ _
-
_When you must not use it _
Do not use Metohexal if you:
• With partial heat block
• Have severe heart failure
• With sinus bradycardia (sinus rhythm with
a resting heart rate less than 45-50 beats/min
• With abnormal heart beat
• Have seriously poor blood circulation
• Are suffering from shock, due to your heart
not pumping properly (cardiogenic shock)
• Have rare tumor in adrenal gland
(phaeochromocytoma)
• Have very low blood pressure
(hypotension)
• With obstructive airway disease or
breathing difficulties of asthma
• Have heart attack with a very slow heart
rate (less than 45 to 50 beats per minute)
-
_Before you start to use it _
Tell your doctor if you:
• Have ever had reaction or been told that
you are allergic to metaprolol tartrate or any
other medicines in beta blocker group or any
of the other Metohexal
ingredients
• Have any breathing problems
• Have any heart problems
�

Ciri produk

PRODUCT DESCRIPTION
METOHEXAL 50 TABLET: Each tablet contains metoprolol
tartrate 50.0 mg
METOHEXAL 100 TABLET: Each tablet contains metoprolol
tartrate 100.0 mg.
PHARMACODYNAMICS
Metoprolol is a beta
1
-selective beta-blocker, i.e. it blocks beta
1
-
receptors
in
the
heart
at
doses
considerably
lower
than
required for blocking beta
2
-receptors.
Metoprolol
has
only
an
insignificant
membrane
stabilizing
effect, and it does not possess an agonist effect. Metoprolol
reduces or
blocks the stimulating effect of catecholamines
(released especially in association with physical and mental
stress)
on
the
heart.
Metoprolol
reduces
the
tachycardia,
increased cardiac output and increased contractility of the heart
usually caused by the sudden increase of catecholamines, as
well as lowers blood pressure. It is classified as cardioselective
lacking intrinsic sympathomimetic and membrane stabilising
activity.
The
plasma
concentration
and
efficacy
(beta
1
-blockade)
of
metoprolol prolonged-release tablets are more even over a
given 24-hour period than those achieved with conventional
tablet forms of beta
1
-selective beta-blockers.
Since the plasma concentrations are stable, the clinical beta
1
-
selectivity is better than that achieved with conventional tablet
forms of beta
1
-selective beta-blockers. Moreover, the risk of
adverse
effects
associated
with
concentration
peaks
(e.g.
bradycardia and weakness of the limbs) is minimal.
If necessary, metoprolol may be administered concomitantly
with a beta
2
-agonist to patients with symptoms of obstructive
pulmonary disease.
PHARMACOKINETICS
Absorption and distribution
Metoprolol is absorbed totally after an oral dose. Because of
the
extensive
first-pass
metabolism
of
metoprolol
the
bioavailability of a single oral dose is approximately 50%. The
bioavailability of prolonged-release tablets is approximately 20-
30% lower than that of conventional tablets which, however,
does not have a significant clinical effect since the AUC values
(pulse)
will
remain
the
same
as
when
using
convent