Country: Cyprus
Bahasa: Greek
Sumber: Φαρμακευτικών Υπηρεσιών του Υπουργείου Υγείας
MENOTROPIN
ANDREAS CONSTANTINIDES (0000003019) GOLGON 21, LEMESOS, 3025
G03GA02
HUMAN MENOPAUSAL GONADOTROPHIN
150IU
POWDER & SOLVENT FOR SOLUTION FOR INJECTION
MENOTROPIN (8000016195) 150IU
INTRAMUSCULAR USE; ΥΠΟΔΟΡΙΑ ΧΡΗΣΗ
Εθνική Διαδικασία
HUMAN MENOPAUSAL GONADOTROPHIN
Νομικό καθεστώς: Με Ιατρική Συνταγή; 10 AMPS X 150IU WITH 2ML SOLVENT (940054301) 10 AMPOULE - Εγκεκριμένο - Με Ιατρική Συνταγή; 1 VIAL X 150IU WITH 2ML SOLVENT (940054302) 1 VIAL - Εγκεκριμένο - Με Ιατρική Συνταγή
MERIONAL® 150 I.U/75 IU Highly purified Human Menopausal Gonadotrophin (hMG) for i.m. and s.c. injections, standardized with the addition of hCG COMPOSITION _1 vial of active ingredient contains:_ ACTIVE INGREDIENT: Human Follicle Stimulating Hormone (FSH) 75 or 150 I.U.; Human Luteinizing Hormone (LH) 75 or 150 I.U. In order to obtain the indicated LH activity, a spiking with hCG is carried out: 3.5-10.5 I.U. of hCG for a LH activity of 75 IU. 7.0-21.0 IU of hCG for a LH activity of 150 IU. EXCIPIENTS: Lactose Monohydrate _Solvent _1 ml physiological solution (NaCl 0.9%). PROPERTIES/EFFECTS Merional contains human Menopausal Gonadotrophin (hMG), which is extracted from the urine of postmenopausal women. In order to obtain an equivalent activity of FSH and LH, Merional is standardized by the addition of human chorionic gonadotropin (hCG), which is extracted from the urine of pregnant women. Postmenopausal urine contains FSH and LH, as well as a very small quantity of a substance similar to hCG. According to the present scientific knowledge, there is nothing to suggest that this substance is different from the hCG obtained from pregnancy urine. FSH and LH activity are both needed for the normal maturation of gametes (follicular maturation in women and spermatogenesis in men, as well as for the synthesis of steroids in the gonads). Merional can be used to stimulate these two processes in case of impaired gonad function. Merional can also be used to stimulate a multi-follicular growth in Assisted Reproduction Techniques (ART), such as in-vitro fecondation (IVF), embryo transfer (ET) and gamete intrafallopian transplant (GIFT). Generally, Merional is used in association with a gonadotropin with LH activity (human chorionic gonadotropin, hCG). HMG and hCG are administered in succession (in women to induce ovulation or controlled superovulation) or at the same time (in men to stimulate Leydig cells). PHARMACOKINETICS FSH and LH are eliminated in two phases. In both phases the biological half-life of FSH is longer than Baca dokumen lengkap