MEDOSTATIN 40MG TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

LOVASTATIN

Boleh didapati daripada:

KOMEDIC SDN BHD

INN (Nama Antarabangsa):

LOVASTATIN

Unit dalam pakej:

100 Tablets

Dikeluarkan oleh:

MEDOCHEMIE LTD (CENTRAL FACTORY)

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP) _
MEDOSTATIN
Lovastatin (20mg, 40mg)
1
WHAT IS IN THIS LEAFLET
1.
What MEDOSTATIN is used for
2.
How MEDOSTATIN works
3.
Before you use MEDOSTATIN
4.
How to use MEDOSTATIN
5.
While you are using it
6.
Side effects
7.
Storage
and
disposal
of
MEDOSTATIN
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT MEDOSTATIN IS USED FOR
MEDOSTATIN may reduce the risk
of heart disease by helping to keep
your
arteries
clear,
even
if
your
cholesterol
levels
are
normal.
MEDOSTATIN
reduces
the
amount
of
cholesterol
in
your
blood.
MEDOSTATIN significantly reduces
the level of LDL (bad) cholesterol and
fatty substances called triglycerides in
your
blood
and
raises
HDL
(good)
cholesterol. LDL-cholesterol is called
“bad”
cholesterol
because
it
is
the
cholesterol
that
clogs
your
arteries.
HDL, on the other hand, is thought to
remove
cholesterol
from
the
blood
vessels and is, therefore, considered to
be “good” cholesterol.
HOW MEDOSTATIN WORKS
Lovastatin
belongs
to
the
group
of
medicines
known
as
statines
or
“HMG-
CoA
reductase
inhibitors”.
These work by reducing the amount of
cholesterol and fatty substances called
triglycerides
in
your
blood.
Cholesterol
is
vital
to
the
normal
functioning of the body, but if levels
of cholesterol in the bloodstream are
too high it can be deposited on the
walls of the arteries. There it builds up
to form plaques which can eventually
block the blood vessel, just like scale
furring-up a water pipe. We only get a
small amount of cholesterol from our
diet; egg yolks and liver contain large
amounts
of
cholesterol,
but
many
foods like fruit, vegetables, and fish
are quite low in cholesterol. Nearly all
of
the
cholesterol
in
our
bodies
is
made by our own livers. The body
produces the most cholesterol at night,
which is why it is recommended that
MEDOSTATIN
is
taken
in
the
evening or at night.
BEFORE YOU USE MEDOSTATIN
_When you must not use it _
Do not take MEDOSTATIN:
-
If you are allergic to lovastatin

Ciri produk

MEDOSTATIN® 20MG AND 40MG TABLETS
LOVASTATIN
PRESENTATION
Tablets containing 20 or 40mg Lovastatin.
MEDOSTATIN 20mg Tablets are blue, round, flat, scored on one side and
8mm in diameter
MEDOSTATIN 40mg Tablets are white, round, flat, scored on one side and
8mm in diameter
(Lovastatin is butanoic
acid-2-methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2(tetrahydro-4hydroxy-6-oxo-2H-pyran-
2yl)ethyl]-1-naphthalenyl ester[1S[1a®*),3a,7β,8β,(25*,45*)8aβ]]
Category:
Lovastatin is an antihyperlipidemic agent classified as an HMG-CoA
reductase inhibitor.
INDICATIONS
MEDOSTATIN (lovastatin) is indicated for the reduction of elevated
total and LDL-cholesterol levels in patients with primary
hypercholesterolemia, when response to the diet and other non-
pharmacological measures alone has been inadequate. It
is also indicated for the reduction of elevated cholesterol levels in
patients with combined hypercholesterolemia and
hypertriglyceridemia, when the hypercholesterolemia is the abnormality
of most concern.
PHARMACOLOGY
_PHARMACODYNAMICS _
MEDOSTATIN (lovastatin) is a cholesterol lowering agent isolated from
a strain of Aspergillus terreus. After oral ingestion
lovastatin, which is an inactive lactone, is hydrolyzed to the
corresponding β-hydroxy acid form. This is a principal metabolite
and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
reductase. This enzyme catalyzes the conversion of
HMG-CoA to mevalonate, which is an early and rate limiting step in the
biosynthesis of cholesterol.
Lovastatin has been shown to reduce both normal and elevated LDL
cholesterol concentrations. LDL is formed from VLDL
and is catabolised predominantly by the high affinity LDL receptor.
The mechanism of the LDL-lowering effect of lovastatin
may involve both reduction of VLDL cholesterol concentration, and
induction of the LDL receptor, leading to reduced
production and/or increased catabolism of LDL cholesterol.
Apolipoprotein B also falls substantially during treatment with
lovastatin. Since each LDL particle contains o