Country: Filipina
Bahasa: Inggeris
Sumber: FDA (Food And Drug Administration)
Amlodipine (As Besilate)
N/A; Importer: Getz Pharma Phils., Inc.; Distributor: Getz Pharma Phils., Inc.
Amlodipine (As Besilate)
5mg
Tablet
Alu/Alu Blister pack x 10's (box of 20's)
Getz Pharma Private Ltd., Pakistan
2022-08-31
CONTRAINDICATIONS 1. Amlodipine is contraindicated in patients with known sensitivity to dihydropyridines, amlodipine or any other components. 2. Amlodipine should not be used in cardiogenic shock, clinically significant aortic stenosis, unstable angina (excluding Prinzmetal’s angina). 3. Amlodipine is contraindicated in patients with severe hypotension (less than 90mmHg systolic). 4. Amlodipine is contraindicated in pregnancy and lactation. 5. Amlodipine is not recommended for use in children. PRECAUTIONS _General:_ The safety and efficacy of amlodipine in hypertensive crisis has not been established. _Hepatic function:_ When amlodipine is used in hepatically impaired patients, the dosage should be carefully and gradually adjusted depending on the patient’s tolerance and response. _Hypotension:_ Careful monitoring of blood pressure is recommended, especially in patients with a history of cerebrovascular insufficiency and those taking medications known to lower blood pressure. _Peripheral Edema:_ Care should be taken to differentiate this peripheral edema from the effects of increasing left ventricular dysfunction. DRUG INTERACTIONS _Cytochrome P450 System:_ Dihydropyridine calcium channel blockers undergo biotransformation by the cytochrome P450 system, mainly via CYP3A4 isoenzyme. Co-administration of amlodipine with other drugs which follow the same route of biotransformation may result in altered bioavailability of amlodipine or these drugs. Dosages of similarly metabolized drugs, particularly those of low therapeutic ratio, and especially in patients with renal and/or hepatic impairment, may require adjustment when starting or stopping concomitantly administered amlodipine to maintain optimum therapeutic blood levels. _Beta-blockers:_ When beta-adrenergic receptor blocking drugs are administered concomitantly with amlodipine, patients should be carefully monitored since blood pressure lowering effect of beta-blockers may be augmented by amlodipine’s reduction in peripheral vascular resistance. _Interac Baca dokumen lengkap