LISINOPRIL tablet LISINOPRIL tablet

Country: Amerika Syarikat

Bahasa: Inggeris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

LISINOPRIL (UNII: E7199S1YWR) (LISINOPRIL ANHYDROUS - UNII:7Q3P4BS2FD)

Boleh didapati daripada:

STAT Rx USA LLC

INN (Nama Antarabangsa):

LISINOPRIL

Komposisi:

LISINOPRIL 20 mg

Laluan pentadbiran:

ORAL

Jenis preskripsi:

PRESCRIPTION DRUG

Tanda-tanda terapeutik:

Lisinopril tablet is indicated for the treatment of hypertension. It may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents. Lisinopril tablet is indicated as adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis. Lisinopril tablet is indicated for the treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction, to improve survival. Patients should receive, as appropriate, the standard recommended treatments such as thrombolytics, aspirin and beta blockers. In using Lisinopril tablet, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that Lisinopril tablet does not have a similar risk (See WARNINGS). In considering the use of Lisinopril tablet, it should

Ringkasan produk:

20 mg Tablets, mottled light yellow, round biconvex uncoated tablets debossed with  "W 941"  on one side and the other side plain.                                                                                        Bottles of 30  -  NDC # 16590-307-30   Bottles of 60  -  NDC # 16590-307-60   Bottles of 90  -  NDC # 16590-307-90   Bottles of 100 - NDC # 16590-307-71 Relabeling and Repackaging by: STAT Rx USA LLC Gainesville, GA  30501

Status kebenaran:

Abbreviated New Drug Application

Ciri produk

LISINOPRIL - LISINOPRIL TABLET
LISINOPRIL - LISINOPRIL TABLET
STAT RX USA LLC
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LISINOPRIL TABLETS USP
USE IN PREGNANCY
WHEN USED IN PREGNANCY DURING THE SECOND AND THIRD TRIMESTERS, ACE
INHIBITORS CAN CAUSE
INJURY AND EVEN DEATH TO THE DEVELOPING FETUS. When pregnancy is
detected, Lisinopril tablet
should be discontinued as soon as possible. See WARNINGS,
Fetal/Neonatal Morbidity and
Mortality.
DESCRIPTION
Lisinopril is an oral long-acting angiotensin converting enzyme
inhibitor. Lisinopril, a synthetic peptide
derivative, is chemically described as (S)-1-[_N_ -(1-carboxy-3-
phenylpropyl)-L-lysyl]-L-proline
dihydrate. Its empirical formula is C
H N O .2H O and its structural formula is:
Lisinopril is a white to off-white, crystalline powder, with a
molecular weight of 441.53. It is soluble
in water and sparingly soluble in methanol and practically insoluble
in ethanol.
Lisinopril tablet is supplied as 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg and
40 mg tablets for oral
administration.
Inactive Ingredients:
2.5 mg, 5 mg, 10 mg tablets - dibasic calcium phosphate dihydrate,
povidone, pregelatinized starch,
mannitol, colloidal silicon dioxide, corn starch, magnesium stearate.
20 mg, 30 mg, 40 mg tablets - dibasic calcium phosphate dihydrate,
povidone, pregelatinized starch,
mannitol, colloidal silicon dioxide, corn starch, magnesium stearate,
ferric oxide yellow (for 20 mg),
ferric oxide red (for 30 mg) and ferric oxide brown (for 40 mg).
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
Lisinopril inhibits angiotensin-converting enzyme (ACE) in human
subjects and animals. ACE is a
peptidyl dipeptidase that catalyzes the conversion of angiotensin I to
the vasoconstrictor substance,
angiotensin II. Angiotensin II also stimulates aldosterone secretion
by the adrenal cortex. The beneficial
effects of lisinopril in hypertension and heart failure appear to
result primarily from suppression of the
reninangiotensin-aldosterone system. Inhibition of ACE results in
decreased plasma angiotensin II
which leads to decreased vasopress