Latacom (Latanoprost 0.005% + Timolol 0.5%) Eye Drops

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Latanoprost; TIMOLOL MALEATE

Boleh didapati daripada:

DUOPHARMA (M) SDN. BHD.

INN (Nama Antarabangsa):

Latanoprost; TIMOLOL MALEATE

Unit dalam pakej:

2.5 ml

Dikeluarkan oleh:

DUOPHARMA (M) SDN. BHD.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
LATACOM (LATANOPROST 0.005% + TIMOLOL 0.5%) EYE DROPS
Latanoprost 50mcg/ml and Timolol 5mg/ml
1
WHAT IS IN THIS LEAFLET
1.
What LATACOM is used for
2.
How LATACOM works
3.
Before you use LATACOM
4.
How to use LATACOM
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
LATACOM
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
11.
Serial Number
WHAT LATACOM IS USED FOR
Reduction of intraocular pressure,
in
patients
with
open
angle
glaucoma
and
ocular
hypertension
who
are
insufficiently responsive to topical
beta-blockers.
LATACOM is used to reduce the
pressure in your eye if you have
conditions known as open angle
glaucoma or ocular hypertension.
Both these conditions are linked
to
an
increase
in
the
pressure
within
your
eye,
eventually
affecting
your
eyesight.
Your
doctor will usually prescribe you
LATACOM when other medicines
have not worked adequately.
HOW LATACOM WORKS
LATACOM
contains
two
medicines:
latanoprost
and
timolol. Latanoprost belongs to a
group
of
medicines
known
as
prostaglandin analogues. Timolol
belongs to a group of medicines
known
as
beta-blockers.
Latanoprost works by increasing
the natural outflow of fluid from
the
eye
into
the
bloodstream.
Timolol
works
by
slowing
the
formation of fluid in the eye.
BEFORE YOU USE LATACOM
LATACOM can be used in adult men
and women (including the elderly),
but is not recommended for use if
you are less than 18 years of age.
_-_
_ _
_When you must not take it _
Do not use LATACOM:
•
If
you
are
allergic
(hypersensitive) to either of the
medicines
in
LATACOM
(latanoprost
or
timolol),
beta-
blockers,
or
any
of
the
other
ingredients of LATACOM.
•
If you have now or have had in
the
past
respiratory
problems
such as asthma, severe chronic
obstructive
bronchitis
(severe
lung
disease
which
may cause
wheeziness,
difficulty
in
breathing and/or long- standing
cough)
•
If
you
have
serious
heart
problems
or
heart
rhythm
disorders.
_Pregnancy and lactation: _
Do

Ciri produk

[DUOPHARMA (M) SDN BHD]
1/4
[20 Apr 2020]
LATACOM (LATANOPROST 0.005% + TIMOLOL 0.5%) EYE DROPS
DESCRIPTION:
Latacom (Latanoprost 0.005% + Timolol 0.5%) Eye Drops : A clear,
colourless solution.
COMPOSITION:
Each 1 ml contains latanoprost 50 micrograms and timolol maleate 6.8
mg equivalent to 5 mg timolol. Contains preservative: benzalkonium
chloride 0.2mg/ml
PHARMACODYNAMICS:
Pharmacotherapeutic group: Ophthalmological-beta-blocking agents -
timolol, combinations
ATC code: S01ED51
Mechanism of action:
Latacom consists of two components: latanoprost and timolol maleate.
These two components decrease elevated intraocular pressure (IOP) by
different mechanisms of action and the
combined effect results in additional IOP reduction compared to either
compound administered alone.
Latanoprost, a prostaglandin F2α analogue, is a selective prostanoid
FP receptor agonist that reduces the IOP by increasing the outflow of
aqueous humour. The main mechanism of action is
increased uveoscleral outflow. Additionally, some increase in outflow
facility (decrease in trabecular outflow resistance) has been reported
in man. Latanoprost has no significant effect on the
production of aqueous humour, the blood-aqueous barrier or the
intraocular blood circulation.
Timolol is a beta-1 and beta-2 (non-selective) adrenergic receptor
blocking agent that has no significant intrinsic sympathomimetic,
direct myocardial depressant or membrane-stabilising
activity. Timolol lowers IOP by decreasing the formation of aqueous in
the ciliary epithelium.
The precise mechanism of action is not clearly established, but
inhibition of the increased cyclic AMP synthesis caused by endogenous
beta-adrenergic stimulation is probable. Timolol has not
been found to significantly affect the permeability of the
blood-aqueous barrier to plasma proteins.
PHARMACOKINETICS
_Latanoprost _
Absorption
Latanoprost is an isopropyl ester prodrug, which per se is inactive
but after hydrolysis by esterases in the cornea to the acid of
latanoprost, becomes biologically active