KARVIL TABLETS 25MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

CARVEDILOL

Boleh didapati daripada:

LABORATORIES TORRENT (MALAYSIA) SDN. BHD.

INN (Nama Antarabangsa):

CARVEDILOL

Unit dalam pakej:

10tablet Tablets; 100tablet Tablets; 30tablet Tablets

Dikeluarkan oleh:

TORRENT PHARMACEUTICALS LTD.

Risalah maklumat

KARVIL TABLETS
_ _
Carvedilol Tablets USP (6.25mg, 25mg)
1
_Consumer Medication Information Leaflet (RiMUP)_
WHAT IS IN THIS LEAFLET?
1.
What Karvil is used for
2.
How Karvil works
3.
Before you use Karvil
4.
How to use Karvil
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Karvil
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10. Date of revision
WHAT KARVIL IS USED FOR?
Karvil
contains
a
medicine
called
carvedilol. This belongs to a group of
medicines called ‘beta-blockers’. Karvil
is used to treat the following:

Chronic heart failure.

High blood pressure (hypertension).

Angina (chest pain or discomfort that
happens when your heart isn’t getting
enough oxygen).
HOW KARVIL WORKS

This
helps
to
lower
your
blood
pressure.

If you have chronic heart failure, this
makes it easier for your heart to pump
blood around your body.

If you have angina, this will help stop
the chest pain.
BEFORE YOU USE KARVIL
_When you must not use it _

You are allergic (hypersensitive) to
carvedilol
or
any
of
the
other
ingredients of Karvil.

You have ever had wheezing due to
asthma or other lung diseases.

You
have
severe
fluid
retention
(swelling of your hands, ankles and
feet)
which
is
being
treated
by
medicines
given
into
one
of
your
veins (intravenously).

You have problems with your liver.

You have problems with your heart
(for example ‘heart block’ or slow
heart beat). Karvil is not suitable for
some
people
with
certain
types
of
heart problem.

You have very low blood pressure.

You have a problem with the acid
levels
in
your
blood
(‘metabolic
acidosis’).

You have a growth on one of your
adrenal glands
(‘phaeochromocytoma’).
If you are not sure, talk to your doctor
or pharmacist before taking Karvil.
-
_Before you start use Karvil _
Check with your doctor or pharmacist
before taking Karvil if:
•
You have problems with your
kidneys.

You
have
diabetes
(high
blood
sugar).

You wear contact lenses.

You have probl

Ciri produk

Proposed Prescribing Information
For the use of a Registered Medical Practitioner or a Hospital or a
Laboratory
KARVIL TABLETS 6.25 MG AND
KARVIL TABLETS 25 MG
CARVEDILOL TABLETS USP 6.25 MG AND 25 MG
BRAND OR PRODUCT NAME
KARVIL TABLETS 6.25 MG
KARVIL TABLETS 25 MG
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
KARVIL TABLETS 6.25 MG
Each uncoated tablet contains:
Carvedilol……...6.25mg
KARVIL TABLETS 25 MG
Each uncoated tablet contains:
Carvedilol……...25mg
PRODUCT DESCRIPTION
KARVIL TABLETS 6.25 MG
White to off-white colored, round, flat, uncoated tablets with break
line on one side and
plain on other side.
KARVIL TABLETS 25 MG
White to off-white colored, round, flat, uncoated tablets with break
line on one side and
plain on other side.
DOSAGE FORM
Uncoated Tablet
PHARMACODYNAMICS / PHARMACOKINETICS
PHARMACODYNAMICS
Carvedilol is a multiple action adrenergic receptor blocker with ά1,
β1 and β2 adrenergic
receptor blockade properties. Carvedilol has been shown to have
organ-protective effects.
Carvedilol is a potent antioxidant and a scavenger of reactive oxygen
radicals. Carvedilol is
racemic, and both R(+) and S(-) enantiomers have the same s-adrenergic
receptor blocking
properties and antioxidant properties. Carvedilol has
antiproliferative effects on human
vascular smooth muscle cells. A decrease in oxidative stress has been
reported in clinical
studies by measuring various markers during chronic treatment of
patients with carvedilol.
Carvedilol's β-adrenergic receptor blocking properties are
nonselective for the β1 and β2-
adrenoceptors and are associated with the levorotatory S(-) enantiomer
Carvedilol has no
intrinsic sympathomimetic activity and (like propranolol) it has
membrane stabilising
1
properties.
Carvedilol
suppresses
the
renin-angio-tensin-aldosterone
system
through
β-
blockade, which reduces the release of renin, thus making fluid
retention rare.
Carvedilol
reduces
the
peripheral
vascular
resistance
via
selective
blockade
of
ά1-
adrenoceptors.
Carvedilol
attenuates
the
increase
in
blo