Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESILATE
HEALOL PHARMACEUTICALS SDN. BHD.
AMLODIPINE BESILATE
30tablet Tablets
M/s Aurobindo Pharma Limited (Unit XV)
KARDAM 5 & 10 _Consumer Medication Information Leaflet (RiMUP)_ Amlodipine Besilate Tablets 5 mg & 10 mg 1 WHAT IS IN THIS LEAFLET 1. What Kardam is used for 2. How Kardam works 3. Before you use Kardam 4. How to use Kardam 5. While you are using it 6. Side effects 7. Storage and Disposal of Kardam 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial number WHAT IS KARDAM USED FOR Kardam helps to keep your blood pressure under control. Kardam relaxes your blood vessels and this helps to lower your blood pressure. It may be used on its own or together with other medicines. Kardam may also be used to treat other conditions, for example, chest pain. HOW KARDAM WORKS If you suffer from high blood pressure, Kardam works by relaxing blood vessels, so that blood passes through them more easily. If you suffer from chest pain (angina), Kardam works by improving blood supply to the heart muscle which then receives more oxygen and as a result chest pain is prevented. Kardam does not provide immediate relief of chest pain from angina. BEFORE YOU USE KARDAM _-When you must not use it _ Kardam is contraindicated in patients with a known sensitivity to dihydropyridines. _-Before you start to use it _ Tell your doctor before you start treatment: - if you have Kidney failure - if you have impaired Liver function _ _ _-Taking other medications _ Inform your doctor and pharmacist if you are taking any other medicines, especially those listed here: - any other medicines for high blood pressure or heart disease - antiviral medicines such as ritonavir - antifungal medicines such as itraconazole, ketoconazole Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription. PREGNANCY AND BREAST FEEDING Kardam should not be administered during pregnancy or lactation or to women of childbearing potential unless effective contraception is used. HOW TO USE KARDAM _-How much to use _ _In _ _ Baca dokumen lengkap
PACKAGE INSERT _Rx Only_ KARDAM Amlodipine Besilate Tablets 5 mg and 10 mg PHARMACODYNAMIC PROPERTIES Amlodipine besilate is a calcium ion influx inhibitor of the dihydropyridine group (slow channel-blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into the cardiac and vascular smooth muscle. The mechanism of the antihypertensive action of Amlodipine besilate is due to a direct relaxant effect on vascular smooth muscle. Amlodipine besilate reduces total ischemic burden by the following two actions: 1) Amlodipine besilate dilates peripheral arterioles and thus, reduces the total peripheral resistance (after load) against which the heart works. Since the heart rate remains stable, this unloading of the heart reduces myocardial energy consumption and oxygen requirements. STRENGTH: 5 mg and 10 mg. PHARMACEUTICAL DOSAGE FORM:Tablet. ROUTE OF ADMINISTRATION: Oral QUALITATIVE AND QUANTITATIVE COMPOSITIONS: 2) The mechanism of action of Amlodipine besilate also probably involves dilatation of the main coronary arteries and coronary arterioles, both in normal and ischaemic regions. This dilatation increases myocardial oxygen delivery in patients with coronary artery spasm (Prinzmetal's or variant angina). In patients with hypertension, once daily dosing provides clinically significant reductions of blood pressure in both the supine and standing positions throughout the 24 hour interval. Due to the slow onset of action, acute hypotension is not a feature of Amlodipine besilate administration. In patients with angina, once daily administration of Amlodipine besilate increases total exercise time, time to angina onset and time to 1 mm ST segment depression and decreases both angina attack frequency and glyceryl trinitrate tablet consumption. PHARMACEUTICAL FORM: _Amlodipine Besilate Tablets 5 mg: _White to off white, flat, bevel edged, barrel shaped, uncoated tablets debossed with 'C' on one side and '58' on the other side. _Amlodipine Besilate Tablets 10 mg:_ White to off white, flat, Baca dokumen lengkap