Country: New Zealand
Bahasa: Inggeris
Sumber: Medsafe (Medicines Safety Authority)
Isoprenaline hydrochloride 0.2 mg/mL; ; Isoprenaline hydrochloride 200 µg/mL
Pfizer New Zealand Limited
Isoprenaline hydrochloride 0.2 mg/mL
0.2 mg/mL
Solution for injection
Active: Isoprenaline hydrochloride 0.2 mg/mL Excipient: Lactic acid Sodium chloride Sodium lactate Sodium metabisulfite Water for injection Active: Isoprenaline hydrochloride 200 µg/mL Excipient: Citric acid Disodium edetate Hydrochloric acid Nitrogen Sodium chloride Sodium citrate dihydrate Sodium hydroxide Water for injection
Ampoule, glass, 25 x 1mL, 25 mL
Prescription
Prescription
Hospira Boulder, Inc.
Isuprel is indicated for: 1. Mild or transient episodes of heart block that do not require electric shock or pacemaker therapy. 2. Serious episodes of heart block and Adams-Stokes attack (except when caused by ventricular tachycardia of fibrillation). 3. Use in cardiac arrest until electric shock or pacemaker therapy, the treatments of choice, are available. 4. Bronchospasm occurring during anaesthesia. 5. As an adjunct to fluid and electrolyte replacement therapy and the use of other medicines and procedures in the treatment of hypovolaemic and septic shock, low cardiac output (hypoperfusion) states, congestive heart failure, and cardiogenic shock.
Package - Contents - Shelf Life: Ampoule, glass, 25 x 1mL (formulation to 04 Apirl 2014) - 25 mL - 18 months from date of manufacture stored at 2° to 8°C (Refrigerate, do not freeze) - Ampoule, glass, 25 x 1mL - 25 mL - 18 months from date of manufacture stored at or below 25°C protect from light - Ampoule, glass, 10 x 5mL (formulation to 04 Apirl 2014) - 50 mL - 18 months from date of manufacture stored at 2° to 8°C (Refrigerate, do not freeze) - Ampoule, glass, 50 x 1mL (formulation to 04 April 2014) - 50 mL - 18 months from date of manufacture stored at 2° to 8°C (Refrigerate, do not freeze) - Ampoule, glass, 10 x 5mL - 50 mL - 18 months from date of manufacture stored at or below 25°C protect from light
1969-12-31
Data Sheet – New Zealand Hospira 2.0 1 ISUPREL ™ _ _ NAME OF MEDICINE Isoprenaline Hydrochloride 0.2mg/mL Injection PRESENTATION A colourless sterile solution of Isoprenaline hydrochloride in a 1mL or 5mL glass ampoule. Each mL of the sterile non pyrogenic 1:5000 solution contains 0.2mg of Isoprenaline hydrochloride, sodium citrate dihydrate, anhydrous citric acid, sodium chloride, water for injection, and hydrochloric acid or sodium hydroxide (for pH adjustment). _ _ _ _ USES _ACTIONS _ Isoprenaline is a potent non selective beta-adrenergic agonist with low affinity for alpha- adrenergic receptors. Isoprenaline acts primarily on the heart and on smooth muscle of bronchi, skeletal muscle vasculature and the gastrointestinal tract. Isoprenaline increases cardiac output due to its positive inotropic and chronotropic actions and increasing venous return. With usual therapeutic doses, the increase in cardiac output is generally sufficient to maintain or increase systolic blood pressure. Intravenous infusion of isoprenaline also lowers peripheral vascular resistance. The diastolic pressure, therefore, may be expected to fall in normal individuals. Thus the mean pressure may be reduced. The rate of discharge of cardiac pacemakers is increased with isoprenaline. Isoprenaline relaxes most smooth muscle, the most pronounced effect being on bronchial and gastrointestinal smooth muscle. It produces marked relaxation in the smaller bronchi and may even dilate the trachea and main bronchi past the resting diameter. In man, isoprenaline causes less hyperglycaemia than does adrenaline. Isoprenaline and adrenaline are equally effective in stimulating the release of free fatty acids and energy production. _ _ _PHARMACOKINETICS _ Isoprenaline is readily absorbed when given parenterally. The half-life of isoprenaline hydrochloride is brief lasting only a few minutes following intravenous administration and up to 2 hours after subcutaneous administration. Isoprenaline is metabolised by catechol-o-methyl transferase primarily in Baca dokumen lengkap