IRBESAT GH irbesartan 300mg film-coated tablet blister pack

Country: Australia

Bahasa: Inggeris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Irbesartan

Boleh didapati daripada:

Alembic Pharmaceuticals Australia Pty Ltd

INN (Nama Antarabangsa):

Irbesartan

Risalah maklumat

Irbesat GH CMI v1 24 October 2012
Page 1 of 5
CONSUMER MEDICINE INFORMATION
IRBESAT GH
_IRBESARTAN FILM-COATED TABLETS_
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about Irbesat
GH.
It does not contain all the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have benefits and
risks. Your doctor has weighed
the benefits of you taking this
medicine against the risks it will
have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE. You may need to read
it again.
WHAT IRBESAT GH IS USED FOR
Irbesat GH is used to lower high
blood pressure, which doctors
call hypertension.
Everyone has blood pressure.
This pressure helps get your
blood all around your body. Your
blood pressure may be different
at different times of the day,
depending on how busy or
worried you are. You have
hypertension (high blood
pressure) when your blood
pressure stays higher than is
needed, even when you are calm
and relaxed.
There are often no symptoms of
high blood pressure. The only
way of knowing that you have
high blood pressure is to have
your blood pressure checked on
a regular basis.
If high blood pressure is not
treated it can lead to serious
health problems, such as stroke,
heart disease and kidney failure.
Irbesat GH is also used in the
treatment of kidney disease in
patients with high blood pressure
and type 2 diabetes.
_ _
HOW IRBESAT GH WORKS
Irbesat GH belongs to a group of
medicines known as angiotensin-
II receptor antagonists.
Angiotensin II is a substance
produced in the body that causes
blood vessels to narrow. Irbesat
GH blocks angiotensin-II and
therefore widens your blood
vessels, making it easier for your
heart to pump blood throughout
your body. This helps to lower
your blood pressure.
Irbesat GH also slows the
decrease of kidney function in
patients with high blood pressure
and type 2 diabetes.
Your doctor may have prescribed
Irbesat GH for another reason.
Ask your doc

Ciri produk

IRBESAT GH PI v0.3 24Oct12
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PRODUCT INFORMATION
IRBESAT GH
IRBESARTAN FILM-COATED TABLETS
NAME OF THE MEDICINE
Irbesartan is
2-butyl-3-[(2'-(1_H_-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,3-diazaspiro
[4,4] non-1-en-4-one
The chemical structure of irbesartan is:
Molecular Formula: C
25
H
28
N
6
O. CAS Number: 138402-11-6. Molecular Weight: 428.5.
DESCRIPTION
Irbesartan is a white or almost white crystalline powder and is
practically insoluble in water, sparingly
soluble in methanol, slightly soluble in methylene chloride.
Irbesartan is a nonpeptide angiotensin II receptor (AT1 subtype)
antagonist. It is available as 75 mg, 150 mg
or 300 mg film-coated tablets for oral administration. The inactive
ingredients are: lactose; croscarmellose
sodium; povidone; magnesium stearate; opadry II complete film coating
system 30F58652 white (ARPING
107860 consisting of hypromellose, macrogol 4000, titanium dioxide)
PHARMACOLOGY
PHARMACODYNAMICS AND MECHANISM OF ACTION
Irbesartan is a specific antagonist of angiotensin II receptors (AT1
subtype). Angiotensin II is an important
component of the renin-angiotensin system and is involved in the
pathophysiology of hypertension and in
sodium homeostasis. Irbesartan does not require metabolic activation
for its activity.
Irbesartan blocks the potent vasoconstrictor and aldosterone-secreting
effects of angiotensin II by selective
antagonism of the angiotensin II (AT1 subtype) receptors localized on
vascular smooth muscle cells and in
the adrenal cortex. It has no agonist activity at the AT1 receptor and
a much greater affinity (more than
8500-fold) for the AT1 receptor than for the AT2 receptor (a receptor
that has not been shown to be
associated with cardiovascular homeostasis).
Irbesartan does not inhibit enzymes involved in the renin-angiotensin
system (i.e. renin, angiotensin
converting enzyme [ACE]) or affect other hormone receptors or ion
channels involved in the cardiovascular
regulation of blood pressure and sodium homeostasis.
IRBESAT GH PI v0.3 24Oct12
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