Hypercor 5mg Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

BISOPROLOL FUMARATE

Boleh didapati daripada:

IMEKS PHARMA SDN. BHD.

INN (Nama Antarabangsa):

BISOPROLOL FUMARATE

Unit dalam pakej:

10 x 10tablet Tablets; 50 x 10tablet Tablets; 10 x 10 Tablets; 50 x 10 Tablets

Dikeluarkan oleh:

Sriprasit Pharma Co. Ltd.

Ciri produk

_PRODUCT DESCRIPTION _
Yellow heart shaped film coated tablet embossed with “S”, “5”
and breakline on one side,
and breakline on the other side. Each film coated tablet contains 5mg
of bisoprolol fumarate.
_PHARMACODYNAMICS _
Bisoprolol is a β1-selective adrenergic blocking agent. Bisoprolol is
related structurally to
acebutolol, atenolol, and metoprolol in that the drugs contain
substituents in the para
position of the benzene ring; the presence of large substituents in
the para position is
believed to account in part for the selective β1-adrenergic blocking
effect of these drugs. It is
devoid of intrinsic symphathomimetic, membrane-stabilizing properties
and only shows
shows low affinity to the β2- receptor of the smooth muscle of
bronchi and vessels as well as
the β2-receptors concerned with metabolic regulation. At therapeutic
doses bisoprolol is not
to be expected to influence airway resistance and β2-mediated
metabolic effects.
_PHARMACOKINETICS _
Bisoprolol is almost completely absorbed after oral administration,
the absorption is not
affected by the presence of food and it undergoes only minimal
first-pass metabolism. Peak
plasma concentrations are reached 2 to 4 h after oral administration.
It is moderately lipid
soluble and rapidly and widely distributed in the body. Plasma protein
binding is around 30%
to 36%. The bioavalability is 82% to 94%. The distribution volume is
3.5 l/kg. It has a plasma
elimination half-life of 10 to 12 hours increased in patients with
renal or liver impairment.
Total clearance is approximately 15 l/h.
Approximately 50% of a dose is metabolised in the liver to
pharmacologically inactive polar
metabolites
that
are
then
excreted
by
the
kidneys;
the
remaining
50%
is
excreted
unchanged. Bisoprolol is eliminated equally by both liver and renal
and less than 2% by
feces.
_INDICATION _
Hypertension.
Coronary Heart Disease (angina pectoris).
Treatment of stable chronic moderate to severe heart failure with
reduced systolic ventricular
function (ejection fraction ≤ 35 %,