Hovid Lipiduce-10 Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ATORVASTATIN CALCIUM

Boleh didapati daripada:

HOVID BERHAD

INN (Nama Antarabangsa):

ATORVASTATIN CALCIUM

Unit dalam pakej:

30Tablet Tablets

Dikeluarkan oleh:

HOVID BERHAD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
HOVID LIPIDUCE-10 AND 20 TABLET
Atorvastatin (10 mg, 20 mg)
1
WHAT IS IN THIS LEAFLET
1.
What Lipiduce is used for
2.
How Lipiduce works
3.
Before you use Lipiduce
4.
How to use Lipiduce
5.
While you are using Lipiduce
6.
Side effects
7.
After using Lipiduce
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
11.
Serial number
WHAT LIPIDUCE IS USED FOR
Lipiduce belongs to a group of
medicines known as statins, which are
lipid (fat) regulating medicines.
Lipiduce is used to lower lipids known
as cholesterol [total cholesterol,
lowdensity lipoprotein cholesterol
(LDL-C)] and other fats (triglycerides)
and to increase high density lipoprotein
cholesterol (HDL-C) in the blood when
a low fat diet and lifestyle changes on
their own have failed.
Lipiduce can lower the risk for heart
attack, stroke, certain types of heart
surgery, and chest pain in patients who
have heart disease or risk factors for
heart disease such as:
•
Age,
•
smoking,
•
high blood pressure,
•
low HDL-C,
•
heart disease in the family.
Lipiduce can lower the risk for heart
attack or stroke in patients with diabetes
and risk factors such as:
•
Eye problems,
•
kidney problems,
•
smoking, or
•
high blood pressure.
_Cholesterol: _
Everyone has cholesterol and
triglycerides in their blood. They are
types of blood fat needed by the body
for many things, including building cell
walls, making bile acids (which help to
digest food) and certain hormones.
However, too much cholesterol can be a
problem.
Your body makes cholesterol, but it also
comes from food. Normally the body
balances the cholesterol it makes with
the cholesterol it gets from food. This
means if more cholesterol comes from
food, less is made by the body.
However, if you eat a diet high in fat,
your body may not keep this balance
and your cholesterol levels rise. High
cholesterol is more likely to occur with
certain diseases or if you have a family
history of high cholesterol.
When you ha

Ciri produk

LIPIDUCE TABLET
VILIP10-var (MY)
DESCRIPTION
LIPIDUCE-10
White
coloured
film-coated
oval
shaped
tablets,
shallow
convex faces, plain on both sides.
LIPIDUCE-20
White
coloured
film-coated
oval
shaped
tablets,
shallow
convex with "HD" and break bar embossed on one face.
COMPOSITION
Each film-coated tablet contains:
LIPIDUCE-10
Atorvastatin Calcium equivalent to Atorvastatin 10 mg.
LIPIDUCE-20
Atorvastatin Calcium equivalent to Atorvastatin 20 mg.
PHARMACODYNAMICS
Atorvastatin is a selective, competitive inhibitor of 3-Hydroxy-
3-methylglutaryl
coenzyme A
(HMG-CoA)
reductase.
The
inhibition
of
HMG-CoA
reductase
prevents
conversion
of
HMG-CoA to mevalonate, the rate-limiting step in cholesterol
biosynthesis. Inhibition of cholesterol synthesis in the liver leads
to upregulation of low-density lipoprotein (LDL) receptors and an
increase in catabolism of LDL cholesterol. It may also reduce the
production of LDL as a result of inhibition of hepatic synthesis of
very low-density lipoprotein (VLDL), the precursor of LDL.
HMG-CoA
reductase
inhibitors
reduce
LDL-cholesterol,
VLDL-cholesterol, and to a lesser extent, plasma triglyceride
concentrations, and slightly increase high-density lipoprotein
(HDL) concentration.
PHARMACOKINETICS
Atorvastatin
is
rapidly
absorbed
after
oral
administration;
maximum plasma concentration occurs within 1 to 2 hours. It
has
low
absolute
bioavailability
of
about
12%
due
to
presystemic clearance in the gastrointestinal mucosa and / or
first-pass metabolism in the liver, its primary sites of action.
Atorvastatin is 98% bound to plasma proteins. It is metabolized
by ortho- and parahydroxylation and beta- oxidation to active
metabolites. The drug and its metabolites are eliminated
primarily in the bile. The mean plasma elimination half-life is
approximately 14 hours.
INDICATIONS
Atorvastatin is indicated as an adjunct to diet for the treatment
of patients with elevated total cholesterol (total-C), low density
lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), and
triglycerides (TG) and to