Hospira Cefazolin Sodium Powder for Injection

Country: Australia

Bahasa: Inggeris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Cefazolin sodium

Boleh didapati daripada:

Hospira Pty Limited

Kelas:

Medicine Registered

Ciri produk

Product Information - Australia_ _

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HOSPIRA™
 CEFAZOLIN SODIUM POWDER FOR INJECTION 

NAME OF THE MEDICINE 
Cefazolin sodium 

Chemical Name: Sodium (6_R, _7_R_)-3-[[(5-methyl-1,
3, 4-thiadiazol-2-yl)sulphanyl]methyl]-8-oxo-7-
[(1_H_-tetrazol-1-ylacetyl)
amino]-5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylate 
Molecular formula: C
14
H
13
N
8
NaO
4
S
3

Molecular weight: 476.5 
CAS: 27164-46-1 

DESCRIPTION 

Cefazolin sodium is a white to off white crystalline powder with a
solubility in water of greater than 
or equal to 100 mg/mL. Hospira™ Cefazolin Sodium Powder for
Injection contains cefazolin sodium 
as a single ingredient. 

Hospira™ Cefazolin Sodium Powder for Injection is a powder for
parenteral administration following 
reconstitution.  Each vial contains 1.05_ _g of cefazolin
sodium which is approximately equivalent to 1_ _
g of cefazolin.  Each gram of cefazolin sodium contains
48.3_ _mg of sodium. 

PHARMACOLOGY 
MICROBIOLOGY 
_In vitro_ tests demonstrate that the bactericidal action of
cephalosporins results from inhibition of cell 
wall synthesis.  Cefazolin sodium is active against the
following organisms _in vitro_: 

_Staphylococcus aureus_ (penicillin-sensitive and
penicillin-resistant). 
Group A beta-haemolytic streptococci and other strains of streptococci
(many strains of enterococci 
are resistant). 

_Streptococcus pneumoniae _
_ _
_Klebsiella species_ 
_Escherichia _
_coli _
_   Enterobacter _
_aerogenes_ 
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_Proteus _
_mirabilis   Haemophilus _
_influenzae _

Most strains of _Enterobacter cloacae_ and indole-positive _Proteus
(Pr. vulgaris, Pr. morganii, Pr. _
_rettgeri)_ are resistant.  Methicillin-resistant
Staphylococci, _Serratia, Pseudomonas, Acinetobacter _
_calcoaceticus _(formerly _Mima_ and _Herellea_ species) are
almost uniformly resistant to