Hiprex 1g Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

HEXAMINE HIPPURATE

Boleh didapati daripada:

iNova Pharmaceuticals (Singapore) Pte Ltd (incorporated In Singapore) Malaysia Branch

INN (Nama Antarabangsa):

HEXAMINE HIPPURATE

Unit dalam pakej:

20tablet Tablets

Dikeluarkan oleh:

3M HEALTHCARE LTD

Risalah maklumat

1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
HIPREX 1G TABLET
Hexamine hippurate (1g)
WHAT IS IN THIS LEAFLET
1.
What Hiprex 1g tablet is used for
2.
How Hiprex 1g tablet works
3.
Before you use Hiprex 1g tablet
4.
How to use Hiprex 1g tablet
5.
While you are using it
6.
Side effects
7.
Storage and disposal of Hiprex 1g
tablet
8.
Product description
9.
Manufacturer
10.
Product Registration Holder
WHAT HIPREX 1G TABLET IS USED FOR
Hiprex 1g tablet is used to treat
infections of the urinary tract.
HOW HIPREX 1G TABLET WORKS
Hiprex 1g tablet works by killing many
different types of bacteria which cause
urinary tract infection.
BEFORE YOU USE HIPREX 1G TABLET
_-When you must not use it _
Do not use this medicine if you have
an allergy to:
•
any medicine containing
Hexamine hippurate
•
any of the ingredients listed at the
end of this leaflet.
Some of the symptoms of an allergic
reaction may include:
•
shortness of breath
_ _
•
wheezing or difficulty breathing
_ _
•
swelling of the face, lips, tongue or
other parts of the body
_ _
•
rash, itching or hives on the skin.
Do not take this medicine if you:
•
have serious problems with your
kidneys
•
have problems with your liver
•
are severely dehydrated
•
have a condition called metabolic
acidosis (a chemical imbalance in
the blood)
•
are taking antibiotic medicines
called sulphonamides. These can
damage your kidneys when taken
at the same time as Hiprex 1g
tablet.
Do not use this medicine after the
expiry date printed on the pack or if the
packaging is torn or shows signs of
tampering.
If you are not sure whether you should
start using this medicine, talk to your
pharmacist or doctor.
_-Before you start to use it _
Tell your pharmacist if you have
allergies to any other medicines, foods,
preservatives or dyes.
If you are pregnant, trying to become
pregnant or breastfeeding, ask your
pharmacist or doctor for advice before
using Hiprex 1g tablet.
_-Taking other medicines _
Tell your pharmacist or doctor if you
are taking any other medicines,
in

Ciri produk

Colours Used:
Client:
Description:
Cutter Size / Ref:
3M Healthcare Ltd - iNova Pharmaceuticals
Hiprex 1g 20's iNova Malaysia - Page 1 of 2
M00194 - For Submission Only
Part Number:
Proof Number:
Date: 28.02.2019
ONE
Print Process:
3M Order No. 1958
127 x 191mm - Drawing Ref: PE00256 v2
Bar Codes:
Argus: 299 Mini
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ENGLAND
Tel: [phone]
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Email:
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BLACK
Keyline
HIPREX 1G TABLET
PRODUCT DESCRIPTION
A white oblong shaped tablet, coded HX with score line on one face and
plain on the
other face.
PHARMACODYNAMICS
Hexamine owes its antibacterial properties to formaldehyde, a
non-specific bactericide,
which is slowly liberated by hydrolysis at acid pH. Most Gram-positive
and Gram-negative
organisms and fungi are susceptible. Hippuric and mandelic acids have
some antibacterial
activity in vitro, but their contribution to the antibacterial action
of the salts in vivo, beyond
assisting the maintenance of low urinary pH, is uncertain.
Urea-splitting organisms such as
Proteus and some Pseudomonas spp, tend to increase urinary pH and
inhibit the release of
formaldehyde, thereby decreasing the effectiveness of hexamine. Use
with acetohydroxamic
acid, a potent inhibitor of bacterial urease, has been suggested for
urinary infections due to
these organisms. True resistance to formaldehyde does not appear to be
a problem in
clinical use.
PHARMACOKINETICS
Hexamine is readily absorbed from the gastrointestinal tract and
widely distributed in the
body. Under acid conditions hexamine is slowly hydrolysed to
formaldehyde and ammonia:
about 10 to 30% of a dose may be converted in the stomach unless it is
given as an enteric-
coated preparation. Almost no hydrolysis of hexamine takes place at
physiological pH, and
it is therefore virtually inactive in the body. The half-life is
reported to be about 4 hours.
Hexamine is rapidly and almost completely eliminated in the urine, and
provided this is
ac