Country: Singapura
Bahasa: Inggeris
Sumber: HSA (Health Sciences Authority)
Glibenclamide
MERCK PTE. LTD.
A10BD02
5.0mg
TABLET, FILM COATED
ORAL
Prescription Only
Merck Santé s.a.s
2013-03-18
5 2 2 140 140 5 5 5 2 2 10 MC-1528-2014 M C- 152 8- 20 14 M C- 152 8- 20 14 _Other precautions_ _Because this medicinal product contains lactose, it is contraindicated in case of _ _congenital galactosemia, glucose and galactose malabsorption syndrome or in _ _case of lactase deficiency._ _Hypoxic states--_-Cardiovascular collapse (shock) from whatever cause, acute congestive heart failure, acute myocardial infarction, and other conditions characterized by hypoxemia have been associated with lactic acidosis and may also cause prerenal azotemia. When such events occur in patients on GLUCOVANCE therapy, the drug should be promptly discontinued. _Alcohol intake_---Alcohol is known to potentiate the effect of metformin on lactate metabolism. Patients, therefore, should be warned against excessive alcohol intake, acute or chronic, while receiving GLUCOVANCE. Due to its effect on the gluconeogenic capacity of the liver, alcohol may also increase the risk of hypoglycemia. _Impaired hepatic function_--Since impaired hepatic function has been associated with some cases of lactic acidosis, GLUCOVANCE should generally be avoided in patients with clinical or laboratory evidence of hepatic disease. _Vitamin B_ _12_ _ levels_---In controlled clinical trials with metformin of 29 weeks duration, a decrease to subnormal levels of previously normal serum Vitamin B 12 without clinical manifestations, was observed in approximately 7% of patients. Such decrease, possibly due to interference with B 12 absorption from the B 12 -intrinsic factor complex, is, however, very rarely associated with anemia (see ADVERSE REACTIONS) and appears to be rapidly reversible with discontinuation of metformin or Vitamin B 12 supplementation. Measurement of hematologic parameters on an annual basis is advised in patients on metformin and any apparent abnormalities should be appropriately investigated and managed (see PRECAUTIONS: Laboratory Tests) Baca dokumen lengkap