GLUCON TABLET 850MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

METFORMIN HYDROCHLORIDE

Boleh didapati daripada:

APEX PHARMACY MARKETING SDN. BHD.

INN (Nama Antarabangsa):

METFORMIN HYDROCHLORIDE

Unit dalam pakej:

100Tablet Tablets

Dikeluarkan oleh:

DELORBIS PHARMACEUTICALS LTD.

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
_ _
GLUCON TABLET
_ _
Metformin (500mg & 850mg)
1
WHAT IS IN THIS LEAFLET
1. What Glucon is used for
2. How it works
3. Before you use Glucon
4. How to use Glucon
5. While you are using it
6. Side Effects
7. Storage and Disposal of Glucon
8. Product Description
9. Manufacturer
10. Product Registration Holder
11. Date of Revision
WHAT GLUCON IS USED FOR
GLUCON
belongs
to
a
group
of
medicines
called
biguanides.
It
is
indicated
for
treatment
of
type
2
diabetes
mellitus
in
adults,
particularly
in
overweight
patients,
when
dietary
management
and
exercise
alone
does
not
result
in
adequate glycaemic control.
GLUCON may be used:
-
In adults, as monotherapy or
in
combination
with
other
oral
anti-diabetic
agents
or
with insulin.
-
In children from 10 years of
age
and
adolescents,
as
monotherapy
or
in
combination with insulin.
Ask your doctor why you have to
take this medicine.
HOW GLUCON WORKS
In type 2 diabetes, there is too much
sugar (glucose) in your blood. This is
because
your
body
does
not
make
enough insulin or because it makes
insulin that does not work properly.
Insulin is a hormone that allows your
body tissue to take glucose from the
blood and use it for energy or for
storage
for
future
use.
Metformin
works by improving the sensitivity of
your body to insulin. It helps your
body to use glucose in the normal
way again.
BEFORE YOU USE GLUCON
_- When you must not use it _
DO NOT TAKE GLUCON
In case of:

Hypersensitivity
to
metformin
hydrochloride or to any of the
excipients

Serious
problems
with
your
diabetes
in
the
past
called
diabetic ketoacidosis. When you
have
this
you
lose
weight
quickly, feel sick (nausea) or are
sick (vomiting)

Liver or kidney problems

Recently had a severe infection,
injury or trauma (shock)

Dehydrated

Going to have an X-ray where
you will be injected with a dye

Recently had a heart attack or
any heart problems

Severe
circulation
problems
or
difficulty in breathing

Heavy drinker of alcohol

Pregnancy or

Ciri produk

_GLUCON TABLET 500MG_
_GLUCON TABLET 850MG_
COMPOSITION
_GLUCON TABLET 500MG_
contains Metformin HCI 500mg
_GLUCON TABLET 850MG_
contains Metformin HCI 850mg
DESCRIPTION
_GLUCON TABLET 500MG:_
White coloured, film-coated, round, biconvex tablets, 11.0 mm
diameter, with
breakline on one side.
_GLUCON TABLET 850MG: _
White, round, biconvex, film-coated tablets, 13.5mm diameter.
PHARMACODYNAMICS
Metformin is a biguanide with antihyperglycaemic effects, lowering
both basal and postprandial plasma glucose. It
does not stimulate insulin secretion and therefore does not produce
hypoglycaemia.
Metformin may act via 3 mechanisms:
(1) reduction of hepatic glucose production by inhibiting
gluconeogenesis and glycogenolysis (2) in muscle,
by increasing insulin sensitivity, improving peripheral glucose,
uptake and utilisation (3) and delay of intestinal
glucose absorption.
Metformin stimulates intracellular glycogen synthesis by acting on
glycogen synthase.
Metformin increases the transport capacity of all types of membrane
glucose transporters (GLUT).
In humans, independently of its action on glycaemia, metformin has
favourable effects on lipid metabolism. This
has been shown at therapeutic doses in controlled, medium-term or
long-term clinical studies: metformin reduces
total cholesterol, LDL cholesterol and triglyceride levels.
PHARMACOKINETICS
_Absorption:_
After an oral dose of metformin, Tmax is reached in 2.5 hours.
Absolute bioavailability of a 500mg or 850mg
metformin tablet is approximately 50-60% in healthy subjects. After an
oral dose, the non-absorbed fraction
recovered in faeces was 20-30%.
After oral administration, metfomin absorption is saturable and
incomplete. It is assumed that the pharmacokinetics
of metformin absorption is non-linear.
At the usual metformin doses and dosing schedules, steady state plasma
concentrations are reached within 24 to 48
hours and are generally less than 1 μg/ml. In controlled clinical
trials, maximum metformin plasma levels (Cmax)
did not exceed 4 μg/ml, even at maximum doses