GIAGRA 50 (SILDENAFIL CITRATE TABLETS 50MG)

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

SILDENAFIL CITRATE

Boleh didapati daripada:

UNIMED SDN BHD

INN (Nama Antarabangsa):

SILDENAFIL CITRATE

Unit dalam pakej:

1X4'stablet Tablets

Dikeluarkan oleh:

Hetero Labs Limited

Risalah maklumat

_Consumer Medication Information Leaflet (RiMUP)_
1
GIAGRA TABLETS
(SILDENAFIL CITRATE EQUIVALENT TO SILDENAFIL 25MG, 50MG & 100 MG)
WHAT
IS
IN
THIS
LEAFLET?
1.
What GIAGRA is
used for?
2.
How it works
3.
Before
you
use
GIAGRA
4.
How to use GIAGRA
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
GIAGRA
8.
Product Description
9.
Manufacture
r
10.
Product
Registration
Holder
11.
Date of revision
WHAT GIAGRA IS USED
FOR
GIAGRA is indicated for
the
treatment
of
erectile
dysfunction,
which
is
the
inability to achieve or maintain
a penile erection sufficient for
satisfactory
sexual
performance.
In
order
for
GIAGRA
to
be
effective,
sexual stimulation is required.
HOW GIAGRA WORKS
It works by helping to relax the
blood
vessels
in
your
penis,
allowing
blood
to
flow
into
your
penis
when
you
get
sexually
excited.
GIAGRA
will only help
you
to
get
an
erection
if
you
are
sexually
stimulated.
You
should
not
take GIAGRA
if
you
do
not
have erectile
dysfunction.
BEFORE YOU USE GIAGRA
-
When you must not use it
DO NOT TAKE GIAGRA
•
If
you
are
taking
medicines
called
nitrates,
as the combination may
Cause
a
potentially
dangerous
decrease
in
your blood pressure. Tell
your
doctor
if
you
are
taking
any
of
these
medicines which are often
given for relief of angina
pectoris (or “chest pain”).
If you are not certain, ask
your doctor or pharmacist.
•
If you are using any of the
drugs
known
as
nitric
oxide donors such as amyl
nitrite (“poppers”) as the
combination may also lead
to a potentially dangerous
decrease
in
your
blood
pressure.
•
If
you
are
allergic
(hypersensitive)
to
GIAGRA
or
any
of
the
other
ingredients
of
GIAGRA.
•
If you have a severe heart
or liver problem.
•
If you have recently had a
stroke or a heart attack, or
if
you
have
low
blood
pressure.
•
If
you
have
certain
rare
inherited eye diseases
(such
as
retinitis
pigmentosa).
If you have ever had loss
of vision because of non-
arteritic anterior ischaemic
Optic
neuropathy
(NAION)
-
Before you start to use it
Tell your doctor
•
if
you

Ciri produk

GIAGRA 25, 50 & 100
Sildenal Citrate Tablets 25, 50 & 100 mg
GIAGRA 25 (Sildenal Citrate Tablets 25 mg)
Description: Blue colored round, biconvex, lm coated tablets,
debossed with 124 on one side
and J on the other side.
Each film coated tablets contains Sildenafil Citrate 35.12mg is
equivalent to Sildenafil 25mg
GIAGRA 50 (Sildenal Citrate Tablets 50 mg)
Description: Blue colored round, biconvex, scored lm coated
tablets, debossed with 125 on one
side and J on the other side with score line.
Each film coated tablets contains Sildenafil Citrate 70.24mg is
equivalent to Sildenafil 50mg
GIAGRA 100 (Sildenal Citrate Tablets 100 mg)
Description: Blue colored round, biconvex, scored lm coated
tablets, debossed with 126 on one
side and J on the other side with score line.
Each film coated tablets contains Sildenafil Citrate 140.48mg is
equivalent to Sildenafil 100mg
DOSAGE FORMS: Tablet
PHARMACODYNAMICS
Mechanism of action
The physiologic mechanism of erection of the penis involves release of
nitric oxide (NO) in the
corpus cavernosum during sexual stimulation. NO then activates the
enzyme guanylate cyclase,
which results in increased levels of cyclic guanosine monophosphate
(cGMP), producing smooth
muscle relaxation in the corpus cavernosum and allowing inow of
blood. Sildenal has no direct
relaxant effect on isolated human corpus cavernosum, but enhances the
effect of nitric oxide
(NO) by inhibiting phosphodiesterase type 5 (PDE5), which is
responsible for degradation of
cGMP in the corpus cavernosum.
When sexual stimulation causes local release of NO, inhibition of PDE5
by sildenal causes
increased levels of cGMP in the corpus cavernosum, resulting in smooth
muscle relaxation and
inow of blood to the corpus cavernosum. Sildenal at recommended
doses has no effect in the
absence of sexual stimulation.
_In vitro_, sildenal is found to be selective for PDE5. Its effect
is more potent on PDE5 than on other
known phosphodiesterases (10-fold for PDE5, > 80-fold for PDE1, >
700-fold fo