Genoptic

Country: Australia

Bahasa: Inggeris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Gentamicin sulfate

Boleh didapati daripada:

Allergan Australia Pty Ltd

Kelas:

Medicine Registered

Risalah maklumat

GENOPTIC
®

EYE DROPS
_ _ 
[gentamicin sulfate] 

CONSUMER MEDICINE 
INFORMATION  

WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about 
GENOPTIC
®
 eye drops, (including 
how to use the eye drops).  It does 
not contain all the available 
information.  It does not take the 
place of talking to your doctor or 
pharmacist. 

All medicines have risks and 
benefits.  Your doctor has 
weighed the risks of you using 
GENOPTIC
®
 eye drops against 
the benefits they expect it will 
have for you. 

If you have any concerns about 
using/taking this medicine, ask 
your doctor or pharmacist. 

KEEP THIS LEAFLET WITH THE 
MEDICINE.   You may need to read 
it again. 

WHAT 
GENOPTIC
®

EYE 
DROPS ARE USED FOR 

GENOPTIC
®
 eye drops are used 
for the treatment of infections of 
the eye caused by bacteria. These 
include conjunctivitis (an infection 
of the transparent skin that covers 
the inner surface of the eyelid and 
the surface of the eye which 
causes the eye to produce 
discharge, to be itchy and to form 
crusty eyelids); infection of the 
cornea (the front layer of the 
eyeball); corneal ulcers; infection 
of the edges of the eyelids 
including hair follicles and glands; 
infection of the oil producing gland 
that covers the inner surface of 
the eyelid and infection of the tear 
sac. 

_Mechanism of action: _
The active ingredient in 
GENOPTIC
®  
eye drops,  
gentamicin sulfate, belongs to a 
chemical group called the 
aminoglycosides which have an 
antibiotic activity against a wide 
range of bacteria. 

Your doctor may have prescribed 
GENOPTIC
® 
eye drops for 
another reason.  Ask your doctor if 
you have any questions about why 
GENOPTIC
®
 eye drops have been 
prescribed for you. 

BEFORE YOU TAKE 
GENOPTIC
®

EYE DROPS

_ _
_WHEN YOU MUST NOT USE IT _
Do not use GENOPTIC
®
 eye 
drops if: 
1.  you have an allergy to 
GENOPTIC
®
  eye drops

Ciri produk

GENOPTIC
®
 Eye Drops  

NAME OF THE DRUG 
The active constituent of GENOPTIC
®
 eye drops is gentamicin sulfate. 

_(structure of gentamicin)_ 

Gentamicin C
1
:  
R
1
 = R
2
 = CH
3
Gentamicin C
1A
: R
1

= R
2
 = H 
Gentamicin C
2
: R
1

= CH
3

R
2
 = H 

DESCRIPTION 
Gentamicin sulfate is a white to buff hygroscopic powder which is
freely soluble in water, 
ethylene glycol and formamide.  It is practically insoluble in
alcohol, acetone, chloroform and 
ether.  Gentamicin sulfate is a mixture of the sulfates of gentamicin
C
1
, gentamicin C
1A
 and 
gentamicin C
2
.  When dry, gentamicin sulfate contains not less than 590 units of
gentamicin 
per mg. 

CHEMICAL NAME: 
O-3-deoxy-4-C-methyl-3-(methylamino)-
β-L-arabinopyranosyl-(1→6)-
O-[2,6-diamino-2,3,4,6-tetradeoxy-
α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-
streptamine.  
EMPIRICAL FORMULA: Gentamicin 
C
1
: C
21
H
43
N
5
O
7

   Gentamicin 
C
1A
:   
C
19
H
39
N
5
O
7

Gentamicin C
2
:   
C
20
H
41
N
5
O
7

GENOPTIC
®
 eye drops are a sterile, aqueous solution buffered to approximately
pH 7.0 for 
use in the eye.  Each mL contains gentamicin sulfate (equivalent to 3
mg gentamicin) with 
polyvinyl alcohol (LIQUIFILM
®
), disodium edetate, sodium phosphate dibasic, sodium 
chloride, benzalkonium chloride as a preservative and purified
water. 

PHARMACOLOGY 
Gentamicin sulfate is a water soluble antibiotic of the aminoglycoside
group which has 
shown activity against a wide variety of pathogenic gram-negative and
gram-positive 
bacteria.  The gram-positive bacteria against which gentamicin
sulfate is active include 
coagulase positive and negative staphylococci.   

The gram-negative bacteria against which gentamicin sulfate is active
include certain strains 
of _Pseudomonas aeruginosa_, indole positive and indole negative
Proteus species, 
_Escherichia coli, Klebsiella pneumoniae_, (Friedlander's
bacillus), _Haemophilus influenzae _
GENOPTIC
�