Gabapin 600 mg Tablets

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

GABAPENTIN

Boleh didapati daripada:

JETPHARMA SDN. BHD.

INN (Nama Antarabangsa):

GABAPENTIN

Unit dalam pakej:

100Tablet Tablets

Dikeluarkan oleh:

INTAS PHARM LTD

Risalah maklumat

Consumer Medication Information Leaflet (RiMUP)
GABAPIN 600 MG TABLET
Gabapentin 600mg
1
What is in this leaflet
1.
What Gabapin is used for
2.
How Gabapin works
3.
Before you use Gabapin
4.
How to take Gabapin
5.
While
you
are
using
Gabapin
6.
Side effects
7.
Storage
and
Disposal
of
Gabapin
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10. Date of revision
What Gabapin is used for
Gabapin belongs to a group of
medicines used to treat epilepsy
and peripheral neuropathic pain.
Epilepsy:
Gabapin is used to treat various
forms of epilepsy.
Your
doctor
will
prescribe
Gabapin
for
you to
help
treat
your epilepsy when your current
treatment is not fully controlling
your condition. You should take
Gabapin
in
addition
to
your
current
treatment
unless
told
otherwise.
Peripheral
neuropathic
pain:
Gabapin
is
used
to
treat
long
lasting pain caused by damage
to
the
nerves.
A
variety
of
different
diseases
can
cause
peripheral
(primarily
occurring
in
the
legs
and/or
arms)
neuropathic
pain,
such
as
diabetes
or
shingles.
Pain
sensations may be described as
hot,
burning,
throbbing,
shooting,
stabbing,
sharp,
cramping,
aching,
tingling,
numbness, pins and needles etc.
How Gabapin works
Active ingredient of Gabapin is
gabapentin.
The
mechanism
by
which
gabapentin
exerts
its
anticonvulsant
action
is
unknown,
but
in
animal
test
systems
designed
to
detect
anticonvulsant
activity,
gabapentin prevents seizures as
do
other
marketed
anticonvulsants.
The
mechanism
by
which
gabapentin
exerts
its
analgesic
action is unknown, but in animal
models of analgesia, gabapentin
prevents allodynia (pain-related
behavior
in
response
to
a
normally
innocuous
stimulus)
and
hyperalgesia
(exaggerated
response to painful stimuli).
Before you take Finapecia
-When you must not take it
If you are allergic
(hypersensitive) to gabapentin or
any of the other ingredients of
Gabapin.
- Before you start to take it
Take special care with Gabapin.
-
If
you
suffer
from
kidney
problems
your
doctor
may
prescribe
a
different
dosing
schedule.
- If yo

Ciri produk

GABAPIN
(Gabapentin Tablets 600 mg)
NAME AND STRENGTH OF ACTIVE INGREDIENT
Gabapentin 600
DOSAGE FORM
Film Coated Tablet
THERAPEUTIC CODE
Antiepileptics: ATC code NO3AX12
PRODUCT DESCRIPTION
Gabapentin Tablets are available in two strengths: 600 mg
GABAPIN 600 Tablets is White to off white, oval shaped, film coated
tablets plain on
both sides.
PHARMACODYNAMIC PROPERTIES
Gabapentin
is
structurally
related
to
the
neurotransmitter
GABA
(gammaaminobutyric acid) but its mechanism of action is different from
that of
several
other
drugs
that
interact
with
GABA
synapses
including
valproate,
barbiturates,
benzodiazepines,
GABA
transaminase
inhibitors,
GABA
uptake
inhibitors, GABA agonists, and GABA prodrugs.
PHARMACOKINETIC PROPERTIES
Absorption
Following
oral
administration,
peak
plasma
gabapentin
concentrations
are
observed within 2 to 3 hours. Gabapentin bioavailability (fraction of
dose absorbed)
tends to decrease with increasing dose. Absolute bioavailability of a
300 mg capsule
is approximately 60%. Food, including a high-fat diet, has no
clinically significant
effect on gabapentin pharmacokinetics.
Gabapentin pharmacokinetics is not affected by repeated
administration. Although
plasma gabapentin concentrations were generally between 2 μg/ml and
20 μg/ml in
clinical studies, such concentrations were not predictive of safety or
efficacy.
Pharmacokinetic parameters are given in below Table.
Table
-
Summary
of
gabapentin
mean
(%CV)
steady-state
pharmacokinetic
parameters following every eight hours administration
Distribution
Gabapentin is not bound to plasma proteins and has a volume of
distribution equal
to 57.7 litres. In patients with epilepsy, gabapentin concentrations
in cerebrospinal
fluid (CSF) are approximately 20% of corresponding steady-state trough
plasma
concentrations. Gabapentin is present in the breast milk of
breast-feeding women.
Metabolism
There is no evidence of gabapentin metabolism in humans. Gabapentin
does not
induce hepatic mixed function oxidase enzymes responsible for drug
metabolism.
Elimi