FUROSEMIDE tablet

Country: Amerika Syarikat

Bahasa: Inggeris

Sumber: NLM (National Library of Medicine)

Bahan aktif:

furosemide (UNII: 7LXU5N7ZO5) (furosemide - UNII:7LXU5N7ZO5)

Boleh didapati daripada:

Ingenus Pharmaceuticals, LLC

INN (Nama Antarabangsa):

furosemide

Komposisi:

furosemide 20 mg

Jenis preskripsi:

PRESCRIPTION DRUG

Status kebenaran:

Abbreviated New Drug Application

Ciri produk

FUROSEMIDE- FUROSEMIDE TABLET
INGENUS PHARMACEUTICALS, LLC
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FUROSEMIDE TABLETS, USP
RX ONLY
WARNING
FUROSEMIDE IS A POTENT DIURETIC WHICH, IF GIVEN IN EXCESSIVE AMOUNTS,
CAN LEAD TO A PROFOUND
DIURESIS WITH WATER AND ELECTROLYTE DEPLETION. THEREFORE, CAREFUL
MEDICAL SUPERVISION IS REQUIRED
AND DOSE AND DOSE SCHEDULE MUST BE ADJUSTED TO THE INDIVIDUAL
PATIENT'S NEEDS. (SEE DOSAGE
AND ADMINISTRATION.)
DESCRIPTION
Furosemide is a diuretic which is an anthranilic acid derivative.
Furosemide tablets, USP for oral
administration contain furosemide, USP as the active ingredient and
the following inactive ingredients:
corn starch, lactose monohydrate, magnesium stearate, pregelatinized
starch, and sodium starch
glycolate. Chemically, it is
4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide, USP is
available as white to off white round tablets for oral administration
in dosage strengths of 20, 40 and 80
mg. Furosemide, USP is a white to slightly yellow odorless crystalline
powder. It is practically
insoluble in water, soluble in 15 parts of acetone, freely soluble in
dimethylformamide and in solution
of alkali hydroxides; soluble in methanol; sparingly soluble in
alcohol; very slightly soluble in
chloroform.
The CAS Registry Number is 54-31-9.
It has a molecular formula of C
H ClN O S and a molecular weight of 330.75.
The molecular structure is as follows:
Tested by USP Dissolution Test 1
CLINICAL PHARMACOLOGY
Investigations into the mode of action of furosemide have utilized
micropuncture studies in rats, stop
flow experiments in dogs and various clearance studies in both humans
and experimental animals. It has
been demonstrated that furosemide inhibits primarily the absorption of
sodium and chloride not only in
the proximal and distal tubules but also in the loop of Henle. The
high degree of efficacy is largely due
to the unique site of action. The action on the distal tubule is
independent of any inhibitory effect on
carbonic anhydrase and aldosterone.
Recent evidence suggests that furosemide glucuro