FULVICIDE TABLET 500MG

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

GRISEOFULVIN

Boleh didapati daripada:

ZONTRON PHARMACEUTICALS SDN. BHD.

INN (Nama Antarabangsa):

GRISEOFULVIN

Unit dalam pakej:

100 Tablets

Dikeluarkan oleh:

TERAPUTICS SDN BHD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
FULVICIDE TABLET
Griseofulvin (500 mg)
__________________________________________________________________________________________________
1
WHAT IS IN THIS LEAFLET
1.
What Fulvicide Tablet is used for
2.
How Fulvicide Tablet works
3.
Before you use Fulvicide Tablet
4.
How to use Fulvicide Tablet
5.
While you are using it
6.
Side effects
7.
Storage
and
Disposal
of
Fulvicide
Tablet
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT FULVICIDE TABLET IS USED FOR
Fulvicide tablet is used to treat a fungal
infections.
HOW FULVICIDE TABLET WORKS
Fungal infection may occur in the skin of
the body, scalp, hair or nails. Griseofulvin
works by helping newly formed skin, hair
and nails to resist attack by fungi. As the
new
tissue
(keratin)
grows,
the
old
infected keratin is cast off.
BEFORE YOU USE FULVICIDE TABLET
_- When you must not use it _
Do not take this medicine if:

you are allergic to griseofulvin or any
other ingredients of this medicine
(listed in Product Description)
_ _
_- Before you start to use it _
Tell your doctor if:_ _

you have liver impairment

porphyria (Constipation or diarrhea)

you had problem after taking certain
medicines eg penicilins (antibiotics)
_Pregnancy and lactation _

Please
consult
your
doctor
or
pharmacist
if
you
are
pregnant,
planning
for
pregnancy
or
breast-
feeding before using any medicine.

Fulvicide Tablet is not recommended
for use in pregnancy.
_- Taking other medicines _
Tell your doctor if you are using:

Coumarin anticoagulants

Barbiturates such as Primidone
(antifungal effects)

Phenobarbitone (to relieve anxiety)

Doxercalciferol
(to
help
maintain
healthy
levels
of
chronic
kidney
disease)

Phenylbutazone (treating fever, pain,
and inflammation in the body)

Other
sedative
and
hypnotic
drugs
(sleep
disorder)
that
induce
metabolising enzymes.

Oral contraceptives
Tell your doctor if you are taking any
other medicines, including any that you

Ciri produk

PRODUCT LITERATURE
FULVICIDE TABLET 500 MG
Each tablet contains:
Griseofulvin
500 mg
DESCRIPTION
White coloured double scored round odourless tablet with T embossed on
one side.
PHARMACODYNAMICS
Pharmacotherapeutic group: Antifungals for systemic use.
Griseofulvin
is
an
antifungal
antibiotic
that
is
active
in
vivo
against
common
dermatophytes. The antifungal effect is manifested by binding to
tubulin, at distinct
binding sites, thus interferring with the microtubule function and
causing inhibition of
mitosis, and arresting cell division.
The inhibition of fungal mitosis leads to the production of
multinucleate cells of
characteristic morphology.
On entering the systemic circulation, griseofulvin binds to keratin in
keratin precursor
cells, thereby making them resistant to fungal infections. The drug
only reaches the site
of action when hair or skin is replaced by the keratin-griseofulvin
complex.
Griseofulvin then enters the dermatophyte through energy dependent
transport processes
and binds to the fungal microtubules, interferring with, and
inhibiting mitosis, and the
deposition of fungal cell walls.
Mycology:
Griseofulvin has antifungal activity against the following
dermatophytes, although there
is species and strain variability in susceptibility.
_Trichophyton rubrum, T. tonsurans, T. mentagrophytes, T.
interdigitalis, T. verrucosum, _
_T. megnini, T. gallinae,T. Crateriform, T. sulphureum and T.
schoenleinii. Microsporum _
_audouinii, M. Canis, M. gypseum. Epidermophyton floccosum. _
Griseofulvin
has
no
activity
against
dermatophyte
fungi
of
other
genera,
non-
dermatophyte fungi, yeasts, gram positive bacteria, or gram negative
bacteria. If any of
these are cofactors in the pathology of infection, suitable additional
therapy will be
required for their eradication.
PHARMACOKINETICS
Absorption:
The absorption of griseofulvin from the gastrointestinal tract is
varaible and incomplete.
On average, less than 50% of the oral dose is absorbed, but
administration after a fatty
meal and a reduction in particle size w