Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
FLUOROMETHOLONE
Allergan Malaysia Sdn Bhd
FLUOROMETHOLONE
5ml mL
ALLERGAN PHARMACEUTICALS IRELAND
Not Applicable Baca dokumen lengkap
FML ® (fluorometholone 0.1%) LIQUIFILM TM Sterile Ophthalmic Suspension EACH ML CONTAINS: fluorometholone 1 mg with: Liquifilm TM (polyvinyl alcohol) 14 mg, benzalkonium chloride 0.04 mg, edetate disodium, sodium chloride, sodium phosphate monobasic, sodium phosphate dibasic, polysorbate 80, and purified water. ACTIONS Inhibition of the inflammatory response to inciting agents of mechanical, chemical or immunological nature. No generally accepted explanation of this steroid property has been advanced. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A 2 . Adrenocorticosteroids and their derivatives are capable of producing a rise in intraocular pressure. In clinical studies on patients' eyes treated with both dexamethasone and fluorometholone, fluorometholone demonstrated a lower propensity to increase intraocular pressure than did dexamethasone. INDICATIONS For steroid responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe. CONTRAINDICATIONS Acute superficial (or epithelial) herpes simplex keratitis (dendritic keratitis). Fungal diseases of ocular structures. Vaccinia, varicella and most other viral diseases of the cornea and conjunctiva. Mycobacterial infection such as tuberculosis of the eye. Hypersensitivity to the constituents of this medication. WARNINGS Employment of a corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution. Prolonged use may cause increased intraocular pressure in susceptible individuals resulting in glaucoma and infrequent damage to the optic nerve, defects in visual acuity and fields of vision; posterior subcapsular cat Baca dokumen lengkap