Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol
IDAMAN PHARMA MANUFACTURING SDN BHD
Paracetamol
120 ml; 100 ml; 90 ml; 60 ml
IDAMAN PHARMA MANUFACTURING SDN BHD
FEPRIL SUSPENSION 250MG/5ML Paracetamol (250mg /5mL) 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What FEPRIL is used for 2. How FEPRIL works 3. Before you use FEPRIL 4. How to use FEPRIL 5. While you are using FEPRIL 6. Side effects 7. Storage and disposal of FEPRIL 8. Product description 9. Product Registration Holder & Manufacturer 10. Date of revision WHAT FEPRIL IS USED FOR FEPRIL is used for relief of mild to moderate pain and to reduce fever. It provides symptomatic relief only; additional therapy to treat the cause of the pain or fever should be instituted when necessary. HOW FEPRIL WORKS FEPRIL has analgesic (pain relief) and antipyretic (anti-fever) properties. BEFORE YOU USE FEPRIL - _When you must not use it _ Do not take FEPRIL if you are allergic to Paracetamol or Acetaminophen. Do not take FEPRIL if you are pregnant, trying to get pregnant or think you may be pregnant without discussing with your doctor first. Do not take FEPRIL if you are breast- feeding. If you are not sure whether you should start taking this medicine, talk to your doctor or pharmacist. - _Before you start to use it _ Tell your doctor if you have allergies to Paracetamol or Acetaminophen. Your doctor needs to know before you take FEPRIL if you have kidney or liver problem. FEPRIL should be given with care to patients with impaired kidney or liver function. FEPRIL should also be given with care to patients taking other drugs that affect the liver. Your doctor needs to know if you are intolerant of aspirin. Patient intolerant of aspirin may not be intolerant of FEPRIL, however mild bronchospastic reactions with FEPRIL have been reported in some aspirin-sensitive asthmatics. Discuss with your doctor or pharmacist first if you are pregnant or breastfeeding. - _Taking other medicines _ Tell your doctor or pharmacist before taking FEPRIL, if you are taking any other medicines, including any that you buy without a prescription from pharmacy, supermarket or health food shop. The effects of some medicine Baca dokumen lengkap
IDAMAN PHARMA MANUFACTURING FEPRIL SUSPENSION 250MG/5ML DESCRIPTION Viscous, opaque liquid and free from visible impurities. Colour: Orange to orange brownish. Odour: Fruity odour. Each 5ml contains Paracetamol 250mg. PRESERVATIVES Methyl Paraben : 10mg Propyl Paraben : 2.5mg ROUTE OF ADMINISTRATION Oral PHARMACODYNAMICS Paracetamol is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. The mechanism of analgesic action has not been fully determined. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and, to a lesser extent, through a peripheral action by blocking pain impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitise pain receptors to mechanical or chemical stimulation. Paracetamol probably produces antipyresis by acting centrally on the hypothalamic heat regulating centre to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus. PHARMACOKINETICS_ _ ABSORPTION: Rapid and almost complete following oral administration. Paracetamol absorption takes place mainly in the small intestine and therefore the rate of absorption is depending on the rate of gastric emptying. It has been shown that drugs which delay gastric emptying also delay the absorption of paracetamol whereas metoclopramide accelerates absorption of the analgesic through the total amount absorbed doses not increase. The rate of absorption may be decreased if paracetamol is taken following a high carbohydrate meal. Alterations in gastric pH have no appreciable effect on paracetamol absorption. During absorption, the amount of paracetamol which is inactivated is negligible and it has been shown that paracetamol does not affect gastric mucosal permeability and does not produce mucosal bleeding Baca dokumen lengkap