EPINEPHRINE INJECTION USP SOLUTION

Country: Kanada

Bahasa: Inggeris

Sumber: Health Canada

Bahan aktif:

EPINEPHRINE

Boleh didapati daripada:

HIKMA CANADA LIMITED

Kod ATC:

C01CA24

INN (Nama Antarabangsa):

EPINEPHRINE

Dos:

1MG

Borang farmaseutikal:

SOLUTION

Komposisi:

EPINEPHRINE 1MG

Laluan pentadbiran:

INTRAMUSCULAR

Unit dalam pakej:

15G/50G

Jenis preskripsi:

Ethical

Kawasan terapeutik:

ALPHA-AND BETA-ADRENERGIC AGONISTS

Ringkasan produk:

Active ingredient group (AIG) number: 0104871002; AHFS:

Status kebenaran:

APPROVED

Tarikh kebenaran:

2021-05-03

Ciri produk

PRESCRIBING INFORMATION
EPINEPHRINE INJECTION USP
1 mg / mL
Sterile Solution
For Intramuscular (IM), Intravenous (IV), Intratracheal (IT) or
Subcutaneous (SC) Use
SYMPATHOMIMETIC
Hikma Canada Limited
5995 Avebury Road, Suite 804
Mississauga, Ontario
L5R 3P9
DATE OF PREPARATION: April 19, 2022
CONTROL NO: 262620
2
NAME OF DRUG
EPINEPHRINE INJECTION USP
Sterile Solution
THERAPEUTIC CLASSIFICATION
SYMPATHOMIMETIC
EPINEPHRINE INJECTION USP is a parenteral adrenergic (sympathomimetic)
agent and
cardiac stimulant.
ACTION AND CLINICAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. It acts on
both alpha and beta receptor sites of sympathetic effector cells. Its
most prominent actions are on
the beta receptors of the heart, vascular and other smooth muscle.
When given by rapid
intravenous injection, it produces a rapid rise in blood pressure,
mainly systolic, by (1) direct
stimulation of cardiac muscle which increases the strength of
ventricular contraction, (2)
increasing the heart rate and (3) constriction of the arterioles in
the skin, mucosa and splanchnic
areas of the circulation.
When given by slow intravenous injection, epinephrine usually produces
only a moderate rise in
systolic and a fall in diastolic pressure. Although some increase in
pulse pressure occurs, there is
usually no great elevation in mean blood pressure. Accordingly, the
compensatory reflex
mechanisms that come into play with a pronounced increase in blood
pressure do not antagonize
the direct cardiac actions of epinephrine as much as with
catecholamines that have a predominant
action on alpha receptors.
Total peripheral resistance decreases by action of epinephrine on beta
receptors of the skeletal
muscle vasculature and blood flow is thereby enhanced. Usually this
vasodilator effect of the
drug on the circulation predominates so that the modest rise in
systolic pressure which follows
slow injection or absorption is mainly the result of direct cardiac
stimulation and increase in
cardiac output. In