DYNAPRIM SUSPENSION

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

SULPHAMETHOXAZOLE; TRIMETHOPRIM

Boleh didapati daripada:

DYNAPHARM (M) SDN BHD

INN (Nama Antarabangsa):

SULPHAMETHOXAZOLE; TRIMETHOPRIM

Unit dalam pakej:

100 ml; 60 ml

Dikeluarkan oleh:

DYNAPHARM (M) SDN BHD

Risalah maklumat

Consumer Medication Information Leaflet (RiMUP)
DYNAPRIM SUSPENSION
Sulphamethoxazole/Trimethoprim (200mg/40mg)
1
What is in this leaflet
1.
What Dynaprim Suspension is used
for
2.
How Dynaprim Suspension works
3.
Before you use Dynaprim Suspension
4.
How to use Dynaprim Suspension
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Dynaprim
Suspension
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10. Date of revision
What Dynaprim Suspension is used
for
Indicated in the treatment of:
- Condition that causes difficulty in
breathing as a result of constant
blocking of the airways in adults
- Inflammation of both the small
intestine and the colon
- Ear infection in children
- Infection on lungs
- Urinary tract infections
How Dynaprim Suspension works
Dynaprim Suspension contains
Sulphamethoxazole and Trimethoprim
which effective in treating wide range of
bacterial and some protozoa infections.
Before you use Dynaprim Suspension
- When you must not use it
Do not use this medicine if:
- It is infants under 1 month of age
- You have history of hypersensitivity to
Sulphamethoxazole or Trimethoprim.
- You have haematological (blood)
disorders, megaloblastic anaemia and
bone marrow changes or folic-acid
deficiency such as patients receiving
anticonvulsant drugs.
Pregnancy and lactation
Do not take Dynaprim Suspension if you
are pregnant, trying to get pregnant or
think you may be pregnant.
Do not take Dynaprim Suspension if you
are breast-feeding. Ask your doctor or
pharmacist for advice before taking any
medicine.
- Before you start use it
Tell your doctor or pharmacist if you
have:
- Impaired kidney or liver functions
- G-6-PD deficiency
- Folate deficiency
- Severe allergy or bronchial asthma.
- Taking other medicines
Tell your doctor if you are taking any
other medicines, including any that you
buy without a prescription from a
pharmacy, supermarket or health food
shop especially
:
- Anticonvulsant drugs or oral
anticoagulants.
- Pyrimethamine or immunosuppresive
therapy
- Wa

Ciri produk

DYNAPRIM SUSPENSION
MAL19910828AZ
DESCRIPTION:
SUSPENSION
Colour
:
White
Flavour
:
Blended flavour of milk and vanilla
CONTENT:
Each 5 ml contains:
Sulphamethoxazole .................. 200 mg
Trimethoprim .......................... 40 mg
PHARMACODYNAMICS:
Sulphamethoxazole and Trimethoprim interfere with the bacterial
synthesis of tetrahydrofolic acid, and
essential stage in the production of thymidine, purines, and
subsequently nucleic acids. Sulphamethoxazole,
like
the
other
sulphonamides,
inhibits
the
synthesis
of
dihydrofolic
acid
from
p-aminobenzoic
acid.
Trimethoprim inhibits the action of dihydrofolate reductase and
prevents the synthesis of tetrahydrofolic acid
from dihydrofolic acid; although this stage also occurs in man,
Trimethoprim is much less active against the
mammalian
enzyme.
Enhanced
antibacterial
activity
has
been
reported
when
Sulphamethoxazole
and
Trimethoprim are used together in vitro although there is doubt as to
whether sequential blockage of the
bacterial synthetic pathway is responsible. The clinical relevance of
this enhanced activity is uncertain
especially in urinary-tract infections where inhibitory concentrations
of Trimethoprim appear to be dominant.
PHARMACOKINETICS:
Trimethoprim is readily absorbed from the GIT and peak concentrations
occur about 3 hours after a dose is
taken. About 45% of Trimethoprim is bound to plasma proteins. Tissue
concentrations are reported to be higher
than serum concentrations, with particularly high concentrations
occurring in the kidneys and lungs but
concentrations in the cerebrospinal fluid are about one-half of those
in the blood. The half-life is about 10 to
16 hours. About 40 to 50% of a dose is excreted unchanged in the urine
within 24 hours, together with
metabolites. Trimethoprim appears in breast milk.
Sulphamethoxazole is readily absorbed from the GIT and peak plasma
concentrations are reached within 4
hours. Doses of 1 g twice daily should produce blood concentrations of
unconjugated Sulphamethoxazole in
excess of 50 mcg per ml. About 65