DYNA AMPICILLIN 125MG5ML

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

AMPICILLIN

Boleh didapati daripada:

DYNAPHARM (M) SDN BHD

INN (Nama Antarabangsa):

AMPICILLIN

Unit dalam pakej:

60ml mL; 100ml mL

Dikeluarkan oleh:

DYNAPHARM (M) SDN BHD

Risalah maklumat

Consumer Medication Information Leaflet (RiMUP
)
DYNA AMPICILLIN SUSPENSION
Ampicillin Trihydrate (125mg/5ml)
1
What is in ths leaflet
1.
What Dyna Ampicillin is used for
2.
How Dyna Ampicillin works
3.
Before you use Dyna Ampicillin
4.
How to use Dyna Ampicillin
5.
While you are using it
6.
Side effects
7.
Storage and disposal of Dyna
Ampicillin
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
What Dyna Ampicillin is used for
Indicated for the treatment due to the
infections:
-
Ear, nose and throat infections
-
Lower respiratory tract infections
-
Urinary tract infections
-
Skin and soft tissue infections
-
Gonorrhoea and intestine infections
How Dyna Ampicillin works
Ampicillin is a bactericidal antibiotic
which inhibits bacterial cell wall
synthesis. Cell division and growth are
inhibited and death of bacteria
frequently occurs.
Before you use Dyna Ampicillin
- When you must not use it
Do not use Dyna Ampicillin in
individuals with known hypersensitivity
to Penicillin.
Pregnancy and lactation
Do not take Dyna Ampicillin if you are
pregnant, trying to get pregnant or think
you may be pregnant.
Do not take Dyna Ampicillin if you are
breast-feeding.
Ask your doctor or pharmacist for
advice before taking any medicine.
-
Before you start to use it
Tell your doctor or pharmacist if you
have any of the following conditions:
-
Impaired kidney function
-
Hypersensitive to other Penicillins or
Cephalosporins or Penicillamine
-
Taking other medicines
-
May reduce effectiveness of oral
contraceptives.
-
Concurrent administration with
Allopurinol increases incidence of
rashes.
Tell your doctor if you are taking
Probenecid, antacids, alkalising agent
and any other medicines, including any
that you buy without a prescriptions
from a pharmacy, supermarket or health
food shop.
How to use Dyna Ampicillin
-
How much to use
Respiratory-tract or skin infections:
Children 2 - 10 years: 125 mg to 250 mg
every 6 hours.
Children < 2 years: 62.5 mg to 125 mg
every 6 hours.
Gastrointestinal or

Ciri produk

DYNA AMPICILLIN 125MG/5ML
MAL19985980AZ
DESCRIPTION:
Dry Syrup
Colour
:
White (Yellow on adding water)
Flavour
:
Strawberry
CONTENT:
Each 5 ml of the reconstituted suspension contains:
Ampicillin Trihydrate equivalent to Ampicillin .....................
125 mg
Preservative: Sodium Benzoate
......................................... 0.1% w/v
PHARMACODYNAMICS:
Ampicillin is a bactericidal antibiotic which inhibits bacterial cell
wall synthesis, probably by acylation of membrane-
bound transpeptidease enzymes. This prevents cross-linkage of
peptidoglycan chains which is necessary for bacterial
cell wall strength and rigidity. Also, cell division and growth are
inhibited and lysis of susceptible bacteria frequently
occurs. Rapidly dividing bacteria are most susceptible to penicillin
group of antibiotics including Ampicillin.
PHARMACOKINETICS:
Ampicillin is acid stable and 30 to 60% of an oral dose is absorbed.
Peak serum concentrations of 0.8 to 4 mcg/ml are
attained 1 to 2 hours after oral doses of 250 to 500 mg of anhydrate
or trihydrate. The serum half-life is 1 to 2 hours
which is increased in subjects with renal function impairment.
Ampicillin enters most body cavities, tissues and fluids
except the celebrospinal fluid unless the meninges are inflamed, in
which case large amounts may be detectable in
this fluid; Ampicillin crosses the placenta and is excreted in the
milk; volume of distribution about 20 L which in
subjects with cirrhosis may reach about 60 L. About 20% of Ampicillin
is bound to plasma proteins. 30% to 50% of an
oral dose is excreted in the urine in 6 to 8 hours; up to 70% is
excreted in 24 hours; urinary excretion is decreased
after the administration of probenecid; Ampicillin is excreted in the
bile in concentrations up to 4 mcg/ml after an oral
dose of 250 mg; biliary excretion is increased in subjects with
cirrhosis.
INDICATIONS:
Infections caused by sensitive gram-positive organisms, including
Streptococcus pneumoniae, and other streptococci
and
Listeria
monocytogenes.
Gram-negative
microorga