Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CLOBETASOL PROPIONATE
Y.S.P. INDUSTRIES (M) SDN BHD
CLOBETASOL PROPIONATE
10 µg; 15 µg; 15g x 40 Units; 15g x 50 Units; 15g x 72 Units; 20 µg; 100 µg; 500 µg
Y.S.P. INDUSTRIES (M) SDN BHD
DERMOSOL CREAM DESCRIPTION: An off-white to creamy color cream. INGREDIENT(S): Each gram contains: Clobetasol Propionate ........... . . . . . . . . .............................................. 0.5mg ACTION(S): Clobetasol Propionate shares anti-inflammatory, anti-allergic and antipruritic actions. Topical corticosteroids such as Clobetasol Propionate are effective in the treatment of corticosteroid responsive dermatoses primarily because of their anti-inflammatory, antipruritic and vasoconstrictive actions. However while the physiologic, pharmacologic and clinical effects of the corticosteroids are well known, their exact mechanism of actions in each disease are uncertain. PHARMACOLOGY: The extent of percutaneous absorption of topical corticosteroids including Clobetasol Propionate is determined by many factors, including the vehicle, the integrity of the epidermal barrier and the use of occlusive dressings. Clobetasol can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Once absorbed through the skin, topical corticosteroids enter pharmacokinetic pathway similar to systemically administered corticosteroids are bound to plasma proteins. Corticosteroids are metabolised primarily in the liver and are then excreted by the kidney. Some of the Clobetasol Propionate and its metabolites are also excreted into the bile. INDICATION(S): Clobetasol Propionate is indicated for short term treatment of inflammatory and pruritic manifestations of moderate to severe corticosteroid responsive dermatoses, eg. psoriasis (excluding wide spread plaque psoriasis), recalcitrant eczemas, lichen planus, discoid lupus erythematosus and other conditions which do not respond satisfactorily to less active steroids. DOSAGE AND ADMINISTRATION: Should be applied with gentle rubbing to the affected skin areas twice daily, once in the morning and once at night. Therapy should be discontinued when control is achieved. In the more responsive conditions, this may Baca dokumen lengkap