Crystorvas Tablet 40mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ATORVASTATIN CALCIUM TRIHYDRATE

Boleh didapati daripada:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

INN (Nama Antarabangsa):

ATORVASTATIN CALCIUM TRIHYDRATE

Unit dalam pakej:

3x10 Tablets; 10 x 10 Tablets

Dikeluarkan oleh:

DUOPHARMA MANUFACTURING (BANGI) SDN BHD

Risalah maklumat

CRYSTORVAS TABLET
Atorvastatin (40mg; 20mg)
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What Crystorvas is used for
2.
How Crystorvas works
3.
Before you use Crystorvas
4.
How to use Crystorvas
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Crystorvas
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT CRYSTORVAS
IS USED FOR
Crystorvas belongs to a group of
medicines known as statins, which are
lipid (fat) regulating medicines.
Crystorvas is used to lower lipids
known as cholesterol (total cholesterol,
low-density lipoprotein [LDL]
cholesterol) and other fats
(triglycerides) in the blood when a low
fat diet and lifestyle changes on their
own have failed.
Crystorvas can lower the risk for heart
attack, stroke, certain types of heart
surgery, and chest pain in patients who
have heart disease or risk factors for
heart disease such as:
Age, smoking, high blood pressure, low
HDL-C, heart disease in the family.
Crystorvas can lower the risk for heart
attack or stroke in patients with
diabetes and risk factors such as:
Eye problems, kidney problems,
smoking, or high blood pressure.
HOW CRYSTORVAS WORKS
Crystorvas works by reducing the
amount of cholesterol made by the
liver. In terms of good and bad
cholesterol, Crystorvas reduces the bad
cholesterol and raises the good
cholesterol.
BEFORE YOU USE CRYSTORVAS
-
_When you must not use it_
Do not take Crystorvas:
•
if you are hypersensitive (allergic) to
Crystorvas or to any similar
medicines used to lower blood lipids
or to any of the other ingredients of
the medicine;
•
if you have or have ever had a disease
which affects the liver;
•
if you have had any unexplained
abnormal blood tests for liver
function;
•
if you are a woman able to have
•
children and not using reliable
contraception;
•
if you are pregnant or trying to
•
become pregnant;
•
if you are breast-feeding.
_Pregnancy and lactation _
Women of childbearing potential
Women of child-bearing poten

Ciri produk

BRAND NAME: CRYSTORVAS
PRODUCT NAME
CRYSTORVAS TABLET 40MG
CRYSTORVAS TABLET 20MG
ACTIVE INGREDIENT
Crystalline Atorvastatin Calcium
PRODUCT DESCRIPTION
ATORVASTATIN TABLET 40MG - White to off-white, 10 mm round, biconvex,
with “40” marking on one side and plain on the other side,
film-coated tablet.
ATORVASTATIN TABLET 20MG -White to off-white, 7 mm round, biconvex,
with “20” marking on one side and plain on the other side,
film-coated tablet.
PHARMACODYNAMICS Pharmacotherapeutic group: Lipid modifying agents,
HMG-CoA-reductase inhibitors, ATC code: C10AA05
Atorvastatin is a selective, competitive inhibitor of HMG-CoA
reductase, the rate-limiting enzyme responsible for the conversion of
3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, a precursor of
sterols, including cholesterol. Triglycerides and cholesterol in the
liver are incorporated into very low-density lipoproteins (VLDL) and
released into the plasma for delivery to peripheral tissues.
Low-density
lipoprotein (LDL) is formed from VLDL and is catabolised primarily
through the receptor with high affinity to LDL (LDL receptor).
Atorvastatin lowers plasma cholesterol and lipoprotein serum
concentrations by inhibiting HMG-CoA reductase and subsequently
cholesterol biosynthesis in the liver and increases the number of
hepatic LDL receptors on the cell surface for enhanced uptake and
catabolism of LDL.
Atorvastatin reduces LDL production and the number of LDL particles.
Atorvastatin produces a profound and sustained increase in LDL
receptor activity coupled with a beneficial change in the quality of
circulating LDL particles. Atorvastatin is effective in reducing LDL-C
in
patients with homozygous familial hypercholesterolaemia, a population
that has not usually responded to lipid-lowering medicinal
products.
Reductions in total-C, LDL-C, and apolipoprotein B have been proven to
reduce risk for cardiovascular events and cardiovascular mortality.
PHARMACOKINETIC
Absorption
Atorvastatin is rapidly absorbed after oral administration; maximum
plasma co