Country: Australia
Bahasa: Inggeris
Sumber: Department of Health (Therapeutic Goods Administration)
cisatracurium besilate
Pfizer Australia Pty Ltd
cisatracurium besilate
Registered
Version: pfpcisai10713 Supersedes: pfpcisai10213 Page 1 of 16 PRODUCT INFORMATION CISATRACURIUM PFIZER CISATRACURIUM BESYLATE NAME OF THE MEDICINE The chemical name of cisatracurium besylate is (1R,1’R,2R,2’R,)-2,2’-(3,11-dioxo-4,10- dioxatridecamethylene) bis (1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1- veratrylisoquinolinium) dibenzenesulfonate. The molecular formula of cisatracurium besylate is C 65 H 82 N 2 O 18 S 2 and it has a molecular weight of 1243.5. The structural formula is given below: CAS NUMBER: 96946-42-8 DESCRIPTION Cisatracurium besylate is a white to pale yellow powder. CISATRACURIUM PFIZER is supplied in a concentration of 2.68 mg/mL cisatracurium besylate, equivalent to cisatracurium 2 mg/mL. CISATRACURIUM PFIZER also contains Water for Injections and benzenesulfonic acid. CISATRACURIUM PFIZER does not contain any preservative and is for single use in one patient only. Discard any residue. PHARMACOLOGY PHARMACODYNAMICS Cisatracurium besylate, a stereoisomer of atracurium, is an intermediate duration, non- depolarising benzylisoquinolinium skeletal muscle relaxant. Cisatracurium besylate binds to Version: pfpcisai10713 Supersedes: pfpcisai10213 Page 2 of 16 cholinergic receptors on the motor end-plate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anticholinesterase agents such as neostigmine. The ED 95 (dose required to produce 95% depression of the twitch response of the adductor pollicis muscle to stimulation of the ulnar nerve) of cisatracurium besylate is estimated to be 0.05 mg/kg bodyweight during opioid anaesthesia (thiopentone, fentanyl, midazolam). The recommended intubation dose for cisatracurium besylate in adults is 3 × ED 95 , which has a longer clinically effective duration than the recommended intubation dose of atracurium (2 × ED 95 ) (see DOSAGE AND ADMINISTRATION). The ED 95 of cisatracurium besylate in children during halothane anaesthesia is 0.04 mg/kg bodyweight. Ci Baca dokumen lengkap